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ENZYME

ENZYME entry: EC 1.1.1.391

Accepted Name
3beta-hydroxycholanate 3-dehydrogenase (NAD(+))
Alternative Name(s)
3beta-hydroxysteroid dehydrogenase
Reaction catalysed
3-oxo-5beta-cholan-24-oate + H(+) + NADH = isolithocholate + NAD(+)
Comment(s)
  • This bacterial enzyme is involved, along with EC 1.1.1.52 or EC 1.1.1.392, in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids).
  • The enzyme catalyzes the reaction in the reduction direction in vivo.
  • Also acts on related 3-oxo bile acids. cf. 1.1.1.393.
Cross-references
BRENDA1.1.1.391
EC2PDB1.1.1.391
ExplorEnz1.1.1.391
PRIAM enzyme-specific profiles1.1.1.391
KEGG Ligand Database for Enzyme Nomenclature1.1.1.391
IUBMB Enzyme Nomenclature1.1.1.391
IntEnz1.1.1.391
MEDLINEFind literature relating to 1.1.1.391
MetaCyc1.1.1.391
Rhea expert-curated reactions1.1.1.391
UniProtKB/Swiss-Prot
C8WJW0, 3BHD1_EGGLEC8WGQ3, 3BHD2_EGGLE

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