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ENZYME entry: EC 1.12.1.3

Accepted Name
Hydrogen dehydrogenase (NADP(+)).
Alternative Name(s)
NADP(+)-linked hydrogenase.
NADP(+)-reducing hydrogenase.
Reaction catalysed
H(2) + NADP(+) <=> H(+) + NADPH
Cofactor(s)
Fe cation; Iron-sulfur; Ni(2+).
Comment(s)
  • The protein from the bacterium Desulfovibrio fructosovorans exclusively functions as a hydrogen dehydrogenase, while the enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4).
  • Different from EC 1.12.1.5.
Cross-references
BRENDA1.12.1.3
EC2PDB1.12.1.3
ExplorEnz1.12.1.3
PRIAM enzyme-specific profiles1.12.1.3
KEGG Ligand Database for Enzyme Nomenclature1.12.1.3
IUBMB Enzyme Nomenclature1.12.1.3
IntEnz1.12.1.3
MEDLINEFind literature relating to 1.12.1.3
MetaCyc1.12.1.3
Rhea expert-curated reactions1.12.1.3
UniProtKB/Swiss-Prot
Q46505, HNDA_DESFR;  Q46506, HNDB_DESFR;  Q46507, HNDC_DESFR;  
Q46508, HNDD_DESFR;  E7FI44, HYD1A_PYRFU;  E7FHU4, HYD1D_PYRFU;  

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