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ENZYME entry: EC 1.12.98.4

Accepted Name
Sulfhydrogenase.
Alternative Name(s)
Sulfur reductase.
Reaction catalysed
H(2) + polysulfide(n) <=> hydrogen sulfide + polysulfide(n-1)
Cofactor(s)
Iron-sulfur.
Comment(s)
  • The enzyme from the hyperthermophilic archaeon Pyrococcus furiosus is part of two heterotetrameric complexes where the beta and gamma subunits function as sulfur reductase and the alpha and delta subunits function as hydrogenases (EC 1.12.1.3 and EC 1.12.1.4).
  • Sulfur can also be used as substrate, but since it is insoluble in aqueous solution and polysulfide is generated abiotically by the reaction of hydrogen sulfide and sulfur, polysulfide is believed to be the true substrate.
  • Formerly EC 1.97.1.3.
Cross-references
BRENDA1.12.98.4
EC2PDB1.12.98.4
ExplorEnz1.12.98.4
PRIAM enzyme-specific profiles1.12.98.4
KEGG Ligand Database for Enzyme Nomenclature1.12.98.4
IUBMB Enzyme Nomenclature1.12.98.4
IntEnz1.12.98.4
MEDLINEFind literature relating to 1.12.98.4
MetaCyc1.12.98.4
UniProtKB/Swiss-Prot
Q8U2E5, HYD1B_PYRFU;  Q8U2E4, HYD1G_PYRFU;  E7FHN9, HYD2B_PYRFU;  
E7FHW8, HYD2G_PYRFU;  

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