ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.13.11.60

Accepted Name

Linoleate 8R-lipoxygenase.

Alternative Name(s)

5,8-linoleate diol synthase (bifunctional enzyme).

7,8-linoleate diol synthase (bifunctional enzyme).

Reaction catalysed

Linoleate + O(2) <=> (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate

Cofactor(s)

Heme.

Comment(s)

The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyze two separate reactions.
Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate, which is subsequently isomerized by the C-terminal P450 heme thiolate domain to (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.5).
The bifunctional enzyme from Gaeumannomyces graminis also catalyzes the oxidation of linoleic acid to (8R,9Z,12Z)-8-hydroperoxyoctadeca- 9,12-dienoate, but its second domain isomerizes it to (7S,8S,9Z,12Z)- 5,8-dihydroxyoctadeca-9,12-dienoate (cf. EC 5.4.4.6).
Formerly EC 1.13.11.44.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature