ENZYME entry: EC 1.14.11.28
Accepted Name |
Proline 3-hydroxylase.
|
Alternative Name(s) |
P-3-H. |
Reaction catalysed |
L-proline + 2-oxoglutarate + O(2) <=> cis-3-hydroxy-L-proline + succinate + CO(2) |
Cofactor(s) |
Fe(2+).
|
Comment(s) |
- Unlike the proline hydroxylases involved in collagen biosynthesis
(EC 1.14.11.2 and EC 1.14.11.7), this enzyme does not require
ascorbate for activity although it does increase the activity of the
enzyme.
- The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-
proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not
substrates.
|
Cross-references |
BRENDA | 1.14.11.28 |
EC2PDB | 1.14.11.28 |
ExplorEnz | 1.14.11.28 |
PRIAM enzyme-specific profiles | 1.14.11.28 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.28 |
IUBMB Enzyme Nomenclature | 1.14.11.28 |
IntEnz | 1.14.11.28 |
MEDLINE | Find literature relating to 1.14.11.28 |
MetaCyc | 1.14.11.28 |
Rhea expert-curated reactions | 1.14.11.28 |
UniProtKB/Swiss-Prot |
|
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