A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.11.28
| Accepted Name |
|---|
| Proline 3-hydroxylase.
|
| Alternative Name(s) |
|---|
| P-3-H. |
| Reaction catalysed |
|---|
| L-proline + 2-oxoglutarate + O(2) <=> cis-3-hydroxy-L-proline + succinate + CO(2) |
| Cofactor(s) |
|---|
| Fe(2+).
|
| Comment(s) |
|---|
- Unlike the proline hydroxylases involved in collagen biosynthesis
(EC 1.14.11.2 and EC 1.14.11.7), this enzyme does not require
ascorbate for activity although it does increase the activity of the
enzyme.
- The enzyme is specific for L-proline as D-proline, trans-4-hydroxy-L-
proline, cis-4-hydroxy-L-proline and 3,4-dehydro-DL-proline are not
substrates.
|
| Cross-references |
|---|
| BRENDA | 1.14.11.28 |
| EC2PDB | 1.14.11.28 |
| ExplorEnz | 1.14.11.28 |
| PRIAM enzyme-specific profiles | 1.14.11.28 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.11.28 |
| IUBMB Enzyme Nomenclature | 1.14.11.28 |
| IntEnz | 1.14.11.28 |
| MEDLINE | Find literature relating to 1.14.11.28 |
| MetaCyc | 1.14.11.28 |
| UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.14.11.-
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