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ENZYME

ENZYME entry: EC 1.14.12.18

PURL: https://purl.expasy.org/enzyme/EC/1.14.12.18
Accepted Name
biphenyl 2,3-dioxygenase
Alternative Name(s)
biphenyl dioxygenase
Reaction catalysed
biphenyl + NADH + O2 + H(+) = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)
Comment(s)
  • The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center.
  • Chlorine-substituted biphenyls can also act as substrates.
  • Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
Cross-references
BRENDA1.14.12.18
EC2PDB1.14.12.18
ExplorEnz1.14.12.18
KEGG Ligand Database for Enzyme Nomenclature1.14.12.18
IUBMB Enzyme Nomenclature1.14.12.18
MEDLINEFind literature relating to 1.14.12.18
MetaCyc1.14.12.18
Rhea expert-curated reactions1.14.12.18
UniProtKB/Swiss-Prot
Q52438, BPHA1_PSES1Q53122, BPHA1_RHOJRQ52439, BPHA2_PSES1
Q53123, BPHA2_RHOJRQ46372, BPHA_COMTEQ52028, BPHA_METFU
P37333, BPHA_PARXLQ46373, BPHE_COMTEP37334, BPHE_PARXL

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