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ENZYME entry: EC 1.14.13.234

Accepted Name
12-dehydrotetracycline 5-monooxygenase.
Reaction catalysed
12-dehydrotetracycline + NADPH + O(2) <=> 5a,11a-dehydrooxytetracycline + NADP(+) + H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces rimosus, is bifunctional, catalyzing two successive monooxygenation reactions.
  • It starts by catalyzing the stereospecific hydroxylation of anhydrotetracycline at C(6) (EC 1.14.13.38).
  • If the released product is captured by EC 1.3.98.4 it is reduced to tetracycline.
  • However, if the released product is recaptured by OxyS, it performs an additional hydroxylation at C(5), producing 5a,11a- dehydrooxytetracycline, which, following the action of EC 1.3.98.4, becomes oxytetracycline.
Cross-references
BRENDA1.14.13.234
EC2PDB1.14.13.234
ExplorEnz1.14.13.234
PRIAM enzyme-specific profiles1.14.13.234
KEGG Ligand Database for Enzyme Nomenclature1.14.13.234
IUBMB Enzyme Nomenclature1.14.13.234
IntEnz1.14.13.234
MEDLINEFind literature relating to 1.14.13.234
MetaCyc1.14.13.234
UniProtKB/Swiss-Prot
L8EUQ6, OXYS_STRR1

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