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ENZYME entry: EC 1.14.14.172

Accepted Name
3,5,6-trichloropyridin-2-ol monooxygenase.
Reaction catalysed
  • 3,5,6-trichloropyridin-2-ol + FADH(2) + O(2) <=> 3,6-dichloropyridine-2,5-dione + Cl(-) + FAD + H(2)O
  • 3,6-dichloropyridine-2,5-diol + FADH(2) + O(2) <=> 6-chloro-3-hydroxypyridine-2,5-dione + Cl(-) + FAD + H(2)O
  • 6-chloropyridine-2,3,5-triol + FADH(2) + O(2) <=> 3,6-dihydroxypyridine-2,5-dione + Cl(-) + FAD + H(2)O
Comment(s)
  • The enzyme, characterized from a number of bacterial species, participates in the degradation of 3,5,6-trichloropyridin-2-ol (TCP), a metabolite of the common organophosphorus insecticide chlorpyrifos.
  • The enzyme is a multifunctional flavin-dependent monooxygenase that displaces three chlorine atoms by attacking three different positions in the substrate.
  • Each reaction catalyzed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH(2) before the monooxygenase could catalyze the next step.
  • The large amount of FADH(2) that is required is generated by a dedicated flavin reductase (TcpX).
  • Cf. EC 1.14.14.173.
Cross-references
BRENDA1.14.14.172
EC2PDB1.14.14.172
ExplorEnz1.14.14.172
PRIAM enzyme-specific profiles1.14.14.172
KEGG Ligand Database for Enzyme Nomenclature1.14.14.172
IUBMB Enzyme Nomenclature1.14.14.172
IntEnz1.14.14.172
MEDLINEFind literature relating to 1.14.14.172
MetaCyc1.14.14.172
Rhea expert-curated reactions1.14.14.172

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