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ENZYME entry: EC

Accepted Name
3,5,6-trichloropyridin-2-ol monooxygenase
Reaction catalysed
  • 3,5,6-trichloropyridin-2-ol + FADH2 + O2 <=> 3,6-dichloropyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
  • 3,6-dichloropyridine-2,5-diol + FADH2 + O2 <=> 6-chloro-3-hydroxypyridine-2,5-dione + chloride + FAD + 2 H(+) + H2O
  • 6-chloropyridine-2,3,5-triol + FADH2 + O2 <=> 3,6-dihydroxypyridine-2,5-dione + chloride + FAD + 3 H(+) + H2O
  • The enzyme, characterized from a number of bacterial species, participates in the degradation of 3,5,6-trichloropyridin-2-ol (TCP), a metabolite of the common organophosphorus insecticide chlorpyrifos.
  • The enzyme is a multifunctional flavin-dependent monooxygenase that displaces three chlorine atoms by attacking three different positions in the substrate.
  • Each reaction catalyzed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH2 before the monooxygenase could catalyze the next step.
  • The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpX). cf. EC
PRIAM enzyme-specific profiles1.14.14.172
KEGG Ligand Database for Enzyme Nomenclature1.14.14.172
IUBMB Enzyme Nomenclature1.14.14.172
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.14.172

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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