ENZYME entry: EC 220.127.116.11
View entry in original ENZYME format
View entry in raw text format (no links)
- 2,4,6-trichlorophenol + FADH(2) + O(2) <=> 2,6-dichlorobenzoquinone + Cl(-) + FAD + H(2)O
- 2,6-dichlorohydroquinone + FADH(2) + O(2) <=> 2-chloro-6-hydroxy-1,4-benzoquinone + Cl(-) + FAD + H(2)O
- The enzyme, characterized from a number of bacterial species,
participates in the degradation of 2,4,6-trichlorophenol, a compound
that has been used for decades as a wood preservative.
- The enzyme is a multifunctional flavin-dependent monooxygenase that
displaces two chlorine atoms by attacking two different positions in
- Each reaction catalyzed by the enzyme displaces a single chlorine and
results in formation of a dione, which must be reduced by FADH(2)
before the monooxygenase could catalyze the second reaction.
- The large amount of FADH(2) that is required is generated by a
dedicated flavin reductase (TcpB).
- Cf. EC 18.104.22.168.
|PRIAM enzyme-specific profiles||22.214.171.124|
|KEGG Ligand Database for Enzyme Nomenclature||126.96.36.199|
|IUBMB Enzyme Nomenclature||188.8.131.52|
|MEDLINE||Find literature relating to 184.108.40.206|
|Rhea expert-curated reactions||220.127.116.11|
entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-