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ENZYME entry: EC 1.14.14.173

Accepted Name
2,4,6-trichlorophenol monooxygenase.
Reaction catalysed
  • 2,4,6-trichlorophenol + FADH(2) + O(2) <=> 2,6-dichlorobenzoquinone + Cl(-) + FAD + H(2)O
  • 2,6-dichlorohydroquinone + FADH(2) + O(2) <=> 2-chloro-6-hydroxy-1,4-benzoquinone + Cl(-) + FAD + H(2)O
Comment(s)
  • The enzyme, characterized from a number of bacterial species, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative.
  • The enzyme is a multifunctional flavin-dependent monooxygenase that displaces two chlorine atoms by attacking two different positions in the substrate.
  • Each reaction catalyzed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH(2) before the monooxygenase could catalyze the second reaction.
  • The large amount of FADH(2) that is required is generated by a dedicated flavin reductase (TcpB).
  • Cf. EC 1.14.14.172.
Cross-references
BRENDA1.14.14.173
EC2PDB1.14.14.173
ExplorEnz1.14.14.173
PRIAM enzyme-specific profiles1.14.14.173
KEGG Ligand Database for Enzyme Nomenclature1.14.14.173
IUBMB Enzyme Nomenclature1.14.14.173
IntEnz1.14.14.173
MEDLINEFind literature relating to 1.14.14.173
MetaCyc1.14.14.173
Rhea expert-curated reactions1.14.14.173

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