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ENZYME

ENZYME entry: EC 1.14.14.173

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.173
Accepted Name
2,4,6-trichlorophenol monooxygenase
Reaction catalysed
2,4,6-trichlorophenol + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + FAD + 2 chloride + 3 H(+)
Comment(s)
  • The enzyme, characterized from Cupriavidus pinatubonensis, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative.
  • The enzyme is a multifunctional flavin-dependent monooxygenase that catalyzes two different reactions to displace two chlorine atoms, a monooxygenase reaction followed by a hydrolysis reaction that takes advantage of the reactivity of the product of the first reaction, 2,6-dichloro-1,4-benzoquinone.
  • The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpB). cf. EC 1.14.14.172.
Cross-references
BRENDA1.14.14.173
EC2PDB1.14.14.173
ExplorEnz1.14.14.173
KEGG Ligand Database for Enzyme Nomenclature1.14.14.173
IUBMB Enzyme Nomenclature1.14.14.173
MEDLINEFind literature relating to 1.14.14.173
MetaCyc1.14.14.173
Rhea expert-curated reactions1.14.14.173
UniProtKB/Swiss-Prot
Q471I2, TCPA_CUPPJ

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