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ENZYME

ENZYME entry: EC 1.14.14.197

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.197
Accepted Name
progesterone 11alpha-monooxygenase
Alternative Name(s)
CYP509C12
CYP68L1
CYP68L8
progesterone 11alpha-hydroxylase
Reaction catalysed
progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 11alpha-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Comment(s)
  • A cytochrome P450 (heme-thiolate) enzyme.
  • The enzyme, isolated from fungi, can hydroxylate testosterone, androst-4-ene-3,17-dione, and 11-deoxycorticosterone, forming the respective 11alpha-hydroxy compounds (cf. EC 1.14.15.4).
  • The CYP509C12 enzyme from Rhizopus arrhizus can also 6-hydroxylate testosterone and 11-deoxycorticosterone, forming the respective beta- hydroxy compounds.
  • Formerly EC 1.14.99.14.
Cross-references
Rhea expert-curated reactions1.14.14.197
ExplorEnz1.14.14.197
IUBMB Enzyme Nomenclature1.14.14.197
BRENDA1.14.14.197
MetaCyc1.14.14.197
KEGG Ligand Database for Enzyme Nomenclature1.14.14.197
MEDLINEFind literature relating to 1.14.14.197

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-