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ENZYME entry: EC 1.14.14.23

Accepted Name
Cholesterol 7-alpha-monooxygenase.
Alternative Name(s)
Cholesterol 7-alpha-hydroxylase.
CYP7A1.
Reaction catalysed
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) <=> 7-alpha-hydroxycholesterol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Catalyzes the first step in the biosynthesis of bile acids.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.17.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.23
EC2PDB1.14.14.23
ExplorEnz1.14.14.23
PRIAM enzyme-specific profiles1.14.14.23
KEGG Ligand Database for Enzyme Nomenclature1.14.14.23
IUBMB Enzyme Nomenclature1.14.14.23
IntEnz1.14.14.23
MEDLINEFind literature relating to 1.14.14.23
MetaCyc1.14.14.23
Rhea expert-curated reactions1.14.14.23
UniProtKB/Swiss-Prot
P46634, CP7A1_CRIGR;  P22680, CP7A1_HUMAN;  Q64505, CP7A1_MOUSE;  
O46491, CP7A1_PIG;  P51542, CP7A1_RABIT;  P18125, CP7A1_RAT;  

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