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ENZYME

ENZYME entry: EC 1.14.14.24

Accepted Name
vitamin D 25-hydroxylase
Alternative Name(s)
CYP2R1
vitamin D2 25-hydroxylase
vitamin D3 25-hydroxylase
Reaction catalysed
calciol + O2 + reduced [NADPH--hemoprotein reductase] = calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • A microsomal enzyme isolated from human and mouse liver that bioactivates vitamin D3.
  • While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is thought to catalyze the reaction in humans in vivo.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.159.
Cross-references
BRENDA1.14.14.24
EC2PDB1.14.14.24
ExplorEnz1.14.14.24
PRIAM enzyme-specific profiles1.14.14.24
KEGG Ligand Database for Enzyme Nomenclature1.14.14.24
IUBMB Enzyme Nomenclature1.14.14.24
IntEnz1.14.14.24
MEDLINEFind literature relating to 1.14.14.24
MetaCyc1.14.14.24
Rhea expert-curated reactions1.14.14.24
UniProtKB/Swiss-Prot
O46658, CP2DP_PIGQ6VVX0, CP2R1_HUMANQ6VVW9, CP2R1_MOUSE

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