ENZYME entry: EC 1.14.14.24
Accepted Name |
Vitamin D 25-hydroxylase.
|
Alternative Name(s) |
CYP2R1. |
Vitamin D(2) 25-hydroxylase. |
Vitamin D(3) 25-hydroxylase. |
Reaction catalysed |
Calciol + O(2) + [reduced NADPH--hemoprotein reductase] <=> calcidiol + [oxidized NADPH--hemoprotein reductase] + H(2)O |
Comment(s) |
- A microsomal enzyme isolated from human and mouse liver that
bioactivates vitamin D(3).
- While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and
CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is
thought to catalyze the reaction in humans in vivo.
- The direct electron donor to the enzyme is EC 1.6.2.4.
- Formerly EC 1.14.13.159.
|
Cross-references |
BRENDA | 1.14.14.24 |
EC2PDB | 1.14.14.24 |
ExplorEnz | 1.14.14.24 |
PRIAM enzyme-specific profiles | 1.14.14.24 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.24 |
IUBMB Enzyme Nomenclature | 1.14.14.24 |
IntEnz | 1.14.14.24 |
MEDLINE | Find literature relating to 1.14.14.24 |
MetaCyc | 1.14.14.24 |
Rhea expert-curated reactions | 1.14.14.24 |
UniProtKB/Swiss-Prot |
|
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