ENZYME entry: EC 1.14.14.24
| Accepted Name |
|---|
| vitamin D 25-hydroxylase.
|
| Alternative Name(s) |
|---|
| CYP2R1. |
| vitamin D2 25-hydroxylase. |
| vitamin D3 25-hydroxylase. |
| Reaction catalysed |
|---|
| calciol + O2 + reduced [NADPH--hemoprotein reductase] <=> calcidiol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| Comment(s) |
|---|
- A microsomal enzyme isolated from human and mouse liver that
bioactivates vitamin D3.
- While multiple isoforms (CYP27A1, CYP2J2/3, CYP3A4, CYP2D25 and
CYP2C11) are able to catalyze the reaction in vitro, only CYP2R1 is
thought to catalyze the reaction in humans in vivo.
- The direct electron donor to the enzyme is EC 1.6.2.4.
- Formerly EC 1.14.13.159.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.24 |
| EC2PDB | 1.14.14.24 |
| ExplorEnz | 1.14.14.24 |
| PRIAM enzyme-specific profiles | 1.14.14.24 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.24 |
| IUBMB Enzyme Nomenclature | 1.14.14.24 |
| IntEnz | 1.14.14.24 |
| MEDLINE | Find literature relating to 1.14.14.24 |
| MetaCyc | 1.14.14.24 |
| Rhea expert-curated reactions | 1.14.14.24 |
| UniProtKB/Swiss-Prot |
|
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