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ENZYME entry: EC 1.14.14.25

Accepted Name
Cholesterol 24-hydroxylase.
Alternative Name(s)
Cholesterol 24-monooxygenase.
Cholesterol 24S-hydroxylase.
CYP46A1.
Cytochrome P450 46A1.
Reaction catalysed
Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (24S)-cholest-5-ene-3-beta,24-diol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme can also produce 25-hydroxycholesterol.
  • In addition, it can further hydroxylate the product to 24,25- dihydroxycholesterol and 24,27-dihydroxycholesterol.
  • This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood- brain barrier whereas cholesterol cannot.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.98.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.25
EC2PDB1.14.14.25
ExplorEnz1.14.14.25
PRIAM enzyme-specific profiles1.14.14.25
KEGG Ligand Database for Enzyme Nomenclature1.14.14.25
IUBMB Enzyme Nomenclature1.14.14.25
IntEnz1.14.14.25
MEDLINEFind literature relating to 1.14.14.25
MetaCyc1.14.14.25
Rhea expert-curated reactions1.14.14.25
UniProtKB/Swiss-Prot
Q9Y6A2, CP46A_HUMAN;  Q9WVK8, CP46A_MOUSE;  

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