A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.14.25
| Accepted Name |
|---|
| Cholesterol 24-hydroxylase.
|
| Alternative Name(s) |
|---|
| Cholesterol 24-monooxygenase. |
| Cholesterol 24S-hydroxylase. |
| CYP46A1. |
| Cytochrome P450 46A1. |
| Reaction catalysed |
|---|
| Cholesterol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (24S)-cholest-5-ene-3-beta,24-diol + [oxidized NADPH--hemoprotein reductase] + H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- The enzyme can also produce 25-hydroxycholesterol.
- In addition, it can further hydroxylate the product to 24,25-
dihydroxycholesterol and 24,27-dihydroxycholesterol.
- This reaction is the first step in the enzymic degradation of
cholesterol in the brain as hydroxycholesterol can pass the blood-
brain barrier whereas cholesterol cannot.
- The direct electron donor to the enzyme is EC 1.6.2.4.
- Formerly EC 1.14.13.98.
|
| Cross-references |
|---|
| PROSITE | PDOC00081 |
| BRENDA | 1.14.14.25 |
| EC2PDB | 1.14.14.25 |
| ExplorEnz | 1.14.14.25 |
| PRIAM enzyme-specific profiles | 1.14.14.25 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.25 |
| IUBMB Enzyme Nomenclature | 1.14.14.25 |
| IntEnz | 1.14.14.25 |
| MEDLINE | Find literature relating to 1.14.14.25 |
| MetaCyc | 1.14.14.25 |
| UniProtKB/Swiss-Prot |
|
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