ENZYME entry: EC 1.14.14.25

Accepted Name

cholesterol 24-hydroxylase

Alternative Name(s)

cholesterol 24-monooxygenase

cholesterol 24S-hydroxylase

CYP46A1

cytochrome P450 46A1

Reaction catalysed

cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]

Comment(s)

The enzyme can also produce 25-hydroxycholesterol.
In addition, it can further hydroxylate the product to 24,25- dihydroxycholesterol and 24,27-dihydroxycholesterol.
This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood- brain barrier whereas cholesterol cannot.
The direct electron donor to the enzyme is EC 1.6.2.4.
Formerly EC 1.14.13.98.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

Rhea expert-curated reactions

UniProtKB/Swiss-Prot

Q9Y6A2, CP46A_HUMAN

Q9WVK8, CP46A_MOUSE

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-