Home  |  Contact

ENZYME entry: EC 1.14.14.25

Accepted Name
cholesterol 24-hydroxylase.
Alternative Name(s)
cholesterol 24-monooxygenase.
cholesterol 24S-hydroxylase.
CYP46A1.
cytochrome P450 46A1.
Reaction catalysed
cholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • The enzyme can also produce 25-hydroxycholesterol.
  • In addition, it can further hydroxylate the product to 24,25- dihydroxycholesterol and 24,27-dihydroxycholesterol.
  • This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood- brain barrier whereas cholesterol cannot.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.98.
Cross-references
BRENDA1.14.14.25
EC2PDB1.14.14.25
ExplorEnz1.14.14.25
PRIAM enzyme-specific profiles1.14.14.25
KEGG Ligand Database for Enzyme Nomenclature1.14.14.25
IUBMB Enzyme Nomenclature1.14.14.25
IntEnz1.14.14.25
MEDLINEFind literature relating to 1.14.14.25
MetaCyc1.14.14.25
Rhea expert-curated reactions1.14.14.25
UniProtKB/Swiss-Prot
Q9Y6A2, CP46A_HUMAN;  Q9WVK8, CP46A_MOUSE;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-