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ENZYME

ENZYME entry: EC 1.14.14.26

Accepted Name
24-hydroxycholesterol 7alpha-hydroxylase
Alternative Name(s)
24-hydroxycholesterol 7alpha-monooxygenase
Reaction catalysed
(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • Found in liver microsomes and in ciliary non-pigmented epithelium.
  • Specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.99.
Cross-references
BRENDA1.14.14.26
EC2PDB1.14.14.26
ExplorEnz1.14.14.26
PRIAM enzyme-specific profiles1.14.14.26
KEGG Ligand Database for Enzyme Nomenclature1.14.14.26
IUBMB Enzyme Nomenclature1.14.14.26
IntEnz1.14.14.26
MEDLINEFind literature relating to 1.14.14.26
MetaCyc1.14.14.26
Rhea expert-curated reactions1.14.14.26
UniProtKB/Swiss-Prot
Q9NYL5, CP39A_HUMANQ9JKJ9, CP39A_MOUSEP22680, CP7A1_HUMAN
Q64505, CP7A1_MOUSEO46491, CP7A1_PIGP51542, CP7A1_RABIT
P18125, CP7A1_RATO75881, CP7B1_HUMANQ60991, CP7B1_MOUSE

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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