ENZYME entry: EC 1.14.14.26

Accepted Name

24-hydroxycholesterol 7-alpha-hydroxylase.

Alternative Name(s)

24-hydroxycholesterol 7-alpha-monooxygenase.

Reaction catalysed

(24S)-cholest-5-ene-3-beta,24-diol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (24S)-cholest-5-ene-3-beta,7-alpha,24-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O

Cofactor(s)

Heme-thiolate.

Comment(s)

Found in liver microsomes and in ciliary non-pigmented epithelium.
Specific for (24S)-cholest-5-ene-3-beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25.
The direct electron donor to the enzyme is EC 1.6.2.4.
Formerly EC 1.14.13.99.

Cross-references

PROSITE

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

1.14.14.26

KEGG Ligand Database for Enzyme Nomenclature

1.14.14.26

IUBMB Enzyme Nomenclature

1.14.14.26

IntEnz

1.14.14.26

MEDLINE

Find literature relating to 1.14.14.26

MetaCyc

1.14.14.26

UniProtKB/Swiss-Prot

Q9NYL5, CP39A_HUMAN;	Q9JKJ9, CP39A_MOUSE;	P22680, CP7A1_HUMAN;
Q64505, CP7A1_MOUSE;	O46491, CP7A1_PIG;	P51542, CP7A1_RABIT;
P18125, CP7A1_RAT;	O75881, CP7B1_HUMAN;	Q60991, CP7B1_MOUSE;

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