ENZYME entry: EC 1.14.14.26
Accepted Name |
24-hydroxycholesterol 7-alpha-hydroxylase.
|
Alternative Name(s) |
24-hydroxycholesterol 7-alpha-monooxygenase. |
Reaction catalysed |
(24S)-cholest-5-ene-3-beta,24-diol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (24S)-cholest-5-ene-3-beta,7-alpha,24-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O |
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- Found in liver microsomes and in ciliary non-pigmented epithelium.
- Specific for (24S)-cholest-5-ene-3-beta,24-diol, which is formed
mostly in the brain by EC 1.14.14.25.
- The direct electron donor to the enzyme is EC 1.6.2.4.
- Formerly EC 1.14.13.99.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.14.14.26 |
EC2PDB | 1.14.14.26 |
ExplorEnz | 1.14.14.26 |
PRIAM enzyme-specific profiles | 1.14.14.26 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.26 |
IUBMB Enzyme Nomenclature | 1.14.14.26 |
IntEnz | 1.14.14.26 |
MEDLINE | Find literature relating to 1.14.14.26 |
MetaCyc | 1.14.14.26 |
Rhea expert-curated reactions | 1.14.14.26 |
UniProtKB/Swiss-Prot |
|
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