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ENZYME entry: EC 1.14.14.26

Accepted Name
24-hydroxycholesterol 7-alpha-hydroxylase.
Alternative Name(s)
24-hydroxycholesterol 7-alpha-monooxygenase.
Reaction catalysed
(24S)-cholest-5-ene-3-beta,24-diol + [reduced NADPH--hemoprotein reductase] + O(2) <=> (24S)-cholest-5-ene-3-beta,7-alpha,24-triol + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • Found in liver microsomes and in ciliary non-pigmented epithelium.
  • Specific for (24S)-cholest-5-ene-3-beta,24-diol, which is formed mostly in the brain by EC 1.14.14.25.
  • The direct electron donor to the enzyme is EC 1.6.2.4.
  • Formerly EC 1.14.13.99.
Cross-references
PROSITEPDOC00081
BRENDA1.14.14.26
EC2PDB1.14.14.26
ExplorEnz1.14.14.26
PRIAM enzyme-specific profiles1.14.14.26
KEGG Ligand Database for Enzyme Nomenclature1.14.14.26
IUBMB Enzyme Nomenclature1.14.14.26
IntEnz1.14.14.26
MEDLINEFind literature relating to 1.14.14.26
MetaCyc1.14.14.26
UniProtKB/Swiss-Prot
Q9NYL5, CP39A_HUMAN;  Q9JKJ9, CP39A_MOUSE;  P22680, CP7A1_HUMAN;  
Q64505, CP7A1_MOUSE;  O46491, CP7A1_PIG;  P51542, CP7A1_RABIT;  
P18125, CP7A1_RAT;  O75881, CP7B1_HUMAN;  Q60991, CP7B1_MOUSE;  

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