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ENZYME entry: EC 1.14.14.26
| Accepted Name |
|---|
| 24-hydroxycholesterol 7alpha-hydroxylase.
|
| Alternative Name(s) |
|---|
| 24-hydroxycholesterol 7alpha-monooxygenase. |
| Reaction catalysed |
|---|
| (24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein reductase] <=> (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] |
| Comment(s) |
|---|
- Found in liver microsomes and in ciliary non-pigmented epithelium.
- Specific for (24S)-cholest-5-ene-3beta,24-diol, which is formed
mostly in the brain by EC 1.14.14.25.
- The direct electron donor to the enzyme is EC 1.6.2.4.
- Formerly EC 1.14.13.99.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.26 |
| EC2PDB | 1.14.14.26 |
| ExplorEnz | 1.14.14.26 |
| PRIAM enzyme-specific profiles | 1.14.14.26 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.26 |
| IUBMB Enzyme Nomenclature | 1.14.14.26 |
| IntEnz | 1.14.14.26 |
| MEDLINE | Find literature relating to 1.14.14.26 |
| MetaCyc | 1.14.14.26 |
| Rhea expert-curated reactions | 1.14.14.26 |
| UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.14.14.-
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