ENZYME entry: EC 1.14.14.46
Accepted Name |
pimeloyl-[acyl-carrier protein] synthase.
|
Alternative Name(s) |
CYP107H1. |
Reaction catalysed |
a C2-C8-saturated long-chain fatty acyl-[ACP] + 3 O2 + 2 reduced [flavodoxin] <=> 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 3 H(+) + 3 H2O + 2 oxidized [flavodoxin] |
Comment(s) |
- Catalyzes an oxidative C-C bond cleavage of long-chain acyl-[acyl-
carrier protein]s of various lengths to generate pimeloyl-[acyl-
carrier protein], an intermediate in the biosynthesis of biotin.
- The preferred substrate of the enzyme from the bacterium Bacillus
subtilis is palmitoyl-[acyl-carrier protein] which then gives
heptanal as the alkanal.
- The mechanism is similar to EC 1.14.15.6, followed by a hydroxylation
step, which may occur spontaneously.
- Formerly EC 1.14.15.12.
|
Cross-references |
BRENDA | 1.14.14.46 |
EC2PDB | 1.14.14.46 |
ExplorEnz | 1.14.14.46 |
PRIAM enzyme-specific profiles | 1.14.14.46 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.46 |
IUBMB Enzyme Nomenclature | 1.14.14.46 |
IntEnz | 1.14.14.46 |
MEDLINE | Find literature relating to 1.14.14.46 |
MetaCyc | 1.14.14.46 |
Rhea expert-curated reactions | 1.14.14.46 |
UniProtKB/Swiss-Prot |
|
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