ENZYME entry: EC 1.14.14.46
| Accepted Name |
|---|
| Pimeloyl-[acyl-carrier protein] synthase.
|
| Alternative Name(s) |
|---|
| CYP107H1. |
| Reaction catalysed |
|---|
| A long-chain acyl-[acyl-carrier protein] + 2 reduced flavodoxin + 3 O(2) <=> pimeloyl-[acyl-carrier protein] + an n-alkanal + 2 oxidized flavodoxin + 3 H(2)O |
| Cofactor(s) |
|---|
| Heme-thiolate.
|
| Comment(s) |
|---|
- Catalyzes an oxidative C-C bond cleavage of long-chain acyl-[acyl-
carrier protein]s of various lengths to generate pimeloyl-[acyl-
carrier protein], an intermediate in the biosynthesis of biotin.
- The preferred substrate of the enzyme from the bacterium Bacillus
subtilis is palmitoyl-[acyl-carrier protein] which then gives
heptanal as the alkanal.
- The mechanism is similar to EC 1.14.15.6, followed by a hydroxylation
step, which may occur spontaneously.
- Formerly EC 1.14.15.12.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.46 |
| EC2PDB | 1.14.14.46 |
| ExplorEnz | 1.14.14.46 |
| PRIAM enzyme-specific profiles | 1.14.14.46 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.46 |
| IUBMB Enzyme Nomenclature | 1.14.14.46 |
| IntEnz | 1.14.14.46 |
| MEDLINE | Find literature relating to 1.14.14.46 |
| MetaCyc | 1.14.14.46 |
| Rhea expert-curated reactions | 1.14.14.46 |
| UniProtKB/Swiss-Prot |
|
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