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ENZYME

ENZYME entry: EC 1.14.14.46

PURL: https://purl.expasy.org/enzyme/EC/1.14.14.46
Accepted Name
pimeloyl-[acyl-carrier protein] synthase
Alternative Name(s)
CYP107H1
Reaction catalysed
a C2-C8-saturated long-chain fatty acyl-[ACP] + 2 reduced [flavodoxin] + 3 O2 = 6-carboxyhexanoyl-[ACP] + a fatty aldehyde + 2 oxidized [flavodoxin] + 3 H2O + 3 H(+)
Comment(s)
  • Catalyzes an oxidative C-C bond cleavage of long-chain acyl-[acyl- carrier protein]s of various lengths to generate pimeloyl-[acyl- carrier protein], an intermediate in the biosynthesis of biotin.
  • The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal.
  • The mechanism is similar to EC 1.14.15.6, followed by a hydroxylation step, which may occur spontaneously.
  • Formerly EC 1.14.15.12.
Cross-references
BRENDA1.14.14.46
EC2PDB1.14.14.46
ExplorEnz1.14.14.46
KEGG Ligand Database for Enzyme Nomenclature1.14.14.46
IUBMB Enzyme Nomenclature1.14.14.46
MEDLINEFind literature relating to 1.14.14.46
MetaCyc1.14.14.46
Rhea expert-curated reactions1.14.14.46
UniProtKB/Swiss-Prot
P53554, BIOI_BACSU

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