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ENZYME entry: EC 1.14.15.6

Accepted Name
Cholesterol monooxygenase (side-chain-cleaving).
Alternative Name(s)
Cholesterol 20-22-desmolase.
Cholesterol C(20-22) desmolase.
Cholesterol desmolase.
Cholesterol side-chain cleavage enzyme.
Cholesterol side-chain-cleaving enzyme.
CYP11A1.
Cytochrome P-450(scc).
Cytochrome p450(scc).
Steroid 20-22 desmolase.
Steroid 20-22-lyase.
Reaction catalysed
Cholesterol + 6 reduced adrenodoxin + 3 O(2) + 6 H(+) <=> pregnenolone + 4-methylpentanal + 6 oxidized adrenodoxin + 4 H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22.
  • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
Cross-references
PROSITEPDOC00081
BRENDA1.14.15.6
EC2PDB1.14.15.6
ExplorEnz1.14.15.6
PRIAM enzyme-specific profiles1.14.15.6
KEGG Ligand Database for Enzyme Nomenclature1.14.15.6
IUBMB Enzyme Nomenclature1.14.15.6
IntEnz1.14.15.6
MEDLINEFind literature relating to 1.14.15.6
MetaCyc1.14.15.6
Rhea expert-curated reactions1.14.15.6
UniProtKB/Swiss-Prot
P00189, CP11A_BOVIN;  P79153, CP11A_CAPHI;  O46515, CP11A_HORSE;  
P05108, CP11A_HUMAN;  Q92045, CP11A_HYPAM;  Q2XV99, CP11A_MACFA;  
Q9EPT4, CP11A_MESAU;  Q9QZ82, CP11A_MOUSE;  Q07217, CP11A_ONCMY;  
P10612, CP11A_PIG;  Q28827, CP11A_RABIT;  P14137, CP11A_RAT;  
P79202, CP11A_SHEEP;  

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