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ENZYME

ENZYME entry: EC 1.14.15.6

PURL: https://purl.expasy.org/enzyme/EC/1.14.15.6
Accepted Name
cholesterol monooxygenase (side-chain-cleaving)
Alternative Name(s)
cholesterol 20-22-desmolase
cholesterol C20-22 desmolase
cholesterol desmolase
cholesterol side-chain cleavage enzyme
cholesterol side-chain-cleaving enzyme
CYP11A1
cytochrome p450scc
cytochrome P-450scc
steroid 20-22 desmolase
steroid 20-22-lyase
Reaction catalysed
6 reduced [adrenodoxin] + cholesterol + 3 O2 + 6 H(+) = 4-methylpentanal + pregnenolone + 6 oxidized [adrenodoxin] + 4 H2O
Comment(s)
  • The reaction proceeds in three stages, with two hydroxylations at C-22 and C-20 preceding scission of the side-chain between carbons 20 and 22.
  • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
Cross-references
BRENDA1.14.15.6
EC2PDB1.14.15.6
ExplorEnz1.14.15.6
KEGG Ligand Database for Enzyme Nomenclature1.14.15.6
IUBMB Enzyme Nomenclature1.14.15.6
MEDLINEFind literature relating to 1.14.15.6
MetaCyc1.14.15.6
Rhea expert-curated reactions1.14.15.6
UniProtKB/Swiss-Prot
P00189, CP11A_BOVINP79153, CP11A_CAPHIO46515, CP11A_HORSE
P05108, CP11A_HUMANQ92045, CP11A_HYPAMQ2XV99, CP11A_MACFA
Q9EPT4, CP11A_MESAUQ9QZ82, CP11A_MOUSEQ07217, CP11A_ONCMY
P10612, CP11A_PIGQ28827, CP11A_RABITP14137, CP11A_RAT
P79202, CP11A_SHEEP

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