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ENZYME

ENZYME entry: EC 1.14.14.50

Accepted Name
tabersonine 3-oxygenase
Alternative Name(s)
CYP71D1V2
T3O
Reaction catalysed
  • 16-methoxytabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • (-)-tabersonine + O2 + reduced [NADPH--hemoprotein reductase] <=> (3R)-1,2-didehydro-3-hydroxy-2,3-dihydrotabersonine + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • This cytochrome P450 enzyme acts on 16-methoxytabersonine, leading to biosynthesis of vindoline in the plant Catharanthus roseus (Madagascar periwinkle).
  • It can also act on tabersonine, resulting in the production of small amounts of vindorosine.
  • The products are unstable and, in the absence of EC 1.1.99.41 will convert into 3-epoxylated compounds.
Cross-references
BRENDA1.14.14.50
EC2PDB1.14.14.50
ExplorEnz1.14.14.50
PRIAM enzyme-specific profiles1.14.14.50
KEGG Ligand Database for Enzyme Nomenclature1.14.14.50
IUBMB Enzyme Nomenclature1.14.14.50
IntEnz1.14.14.50
MEDLINEFind literature relating to 1.14.14.50
MetaCyc1.14.14.50
Rhea expert-curated reactions1.14.14.50
UniProtKB/Swiss-Prot
I1TEM1, T3O_CATRO

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