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ENZYME entry: EC 1.14.14.50

Accepted Name
Tabersonine 3-oxygenase.
Alternative Name(s)
CYP71D1V2.
T3O.
Reaction catalysed
  • 16-methoxytabersonine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + [oxidized NADPH--hemoprotein reductase] + H(2)O
  • Tabersonine + [reduced NADPH--hemoprotein reductase] + O(2) <=> (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + [oxidized NADPH--hemoprotein reductase] + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • This cytochrome P-450 enzyme acts on 16-methoxytabersonine, leading to biosynthesis of vindoline in the plant Catharanthus roseus (Madagascar periwinkle).
  • It can also act on tabersonine, resulting in the production of small amounts of vindorosine.
  • The products are unstable and, in the absence of EC 1.1.99.41 will convert into 3-epoxylated compounds.
Cross-references
BRENDA1.14.14.50
EC2PDB1.14.14.50
ExplorEnz1.14.14.50
PRIAM enzyme-specific profiles1.14.14.50
KEGG Ligand Database for Enzyme Nomenclature1.14.14.50
IUBMB Enzyme Nomenclature1.14.14.50
IntEnz1.14.14.50
MEDLINEFind literature relating to 1.14.14.50
MetaCyc1.14.14.50
Rhea expert-curated reactions1.14.14.50
UniProtKB/Swiss-Prot
I1TEM1, T3O_CATRO

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