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ENZYME

ENZYME entry: EC 1.14.14.73

Accepted Name
albendazole monooxygenase (sufoxide-forming)
Alternative Name(s)
albendazole hydroxylase
albendazole sulfoxidase
CYP1A2
CYP2J2
CYP3A4
Reaction catalysed
  • albendazole + O2 + reduced [NADPH--hemoprotein reductase] = albendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
  • fenbendazole + O2 + reduced [NADPH--hemoprotein reductase] = fenbendazole S-oxide + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • This is one of the activities carried out by some microsomal cytochrome P450 monooxygenases.
  • A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32), but it is estimated that cytochrome P450s are responsible for 70% of the activity.
Cross-references
BRENDA1.14.14.73
EC2PDB1.14.14.73
ExplorEnz1.14.14.73
PRIAM enzyme-specific profiles1.14.14.73
KEGG Ligand Database for Enzyme Nomenclature1.14.14.73
IUBMB Enzyme Nomenclature1.14.14.73
IntEnz1.14.14.73
MEDLINEFind literature relating to 1.14.14.73
MetaCyc1.14.14.73
Rhea expert-curated reactions1.14.14.73
UniProtKB/Swiss-Prot
P51589, CP2J2_HUMANP08684, CP3A4_HUMAN

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