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ENZYME entry: EC 1.14.14.73

Accepted Name
Albendazole monooxygenase (sufoxide-forming).
Alternative Name(s)
Albendazole hydroxylase.
Albendazole sulfoxidase.
CYP1A2.
CYP2J2.
CYP3A4.
Reaction catalysed
  • Albendazole + [reduced NADPH--hemoprotein reductase] + O(2) <=> albendazole S-oxide + [oxidized NADPH--hemoprotein reductase] + H(2)O
  • Fenbendazole + [reduced NADPH--hemoprotein reductase] + O(2) <=> fenbendazole S-oxide + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • This is one of the activities carried out by some microsomal cytochrome P450 monooxygenases.
  • A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32), but it is estimated that cytochrome P450s are responsible for 70% of the activity.
Cross-references
BRENDA1.14.14.73
EC2PDB1.14.14.73
ExplorEnz1.14.14.73
PRIAM enzyme-specific profiles1.14.14.73
KEGG Ligand Database for Enzyme Nomenclature1.14.14.73
IUBMB Enzyme Nomenclature1.14.14.73
IntEnz1.14.14.73
MEDLINEFind literature relating to 1.14.14.73
MetaCyc1.14.14.73
Rhea expert-curated reactions1.14.14.73
UniProtKB/Swiss-Prot
P51589, CP2J2_HUMAN;  P08684, CP3A4_HUMAN;  Q8HYJ9, FMO3_BOVIN;  
Q95LA1, FMO3_CANLF;  P31513, FMO3_HUMAN;  Q8SPQ7, FMO3_MACMU;  
P97501, FMO3_MOUSE;  Q7YS44, FMO3_PANTR;  P32417, FMO3_RABIT;  
Q9EQ76, FMO3_RAT;  

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