ENZYME entry: EC 1.14.14.74
| Accepted Name | ||
|---|---|---|
| albendazole monooxygenase (hydroxylating) | ||
| Alternative Name(s) | ||
| CYP2J2 | ||
| Reaction catalysed | ||
| albendazole + O2 + reduced [NADPH--hemoprotein reductase] = H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] | ||
| Comment(s) | ||
| CYP2J2 is a microsomal cytochrome P450 monooxygenase that catalyzes the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73. | ||
| Cross-references | ||
| BRENDA | 1.14.14.74 | |
| EC2PDB | 1.14.14.74 | |
| ExplorEnz | 1.14.14.74 | |
| PRIAM enzyme-specific profiles | 1.14.14.74 | |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.74 | |
| IUBMB Enzyme Nomenclature | 1.14.14.74 | |
| IntEnz | 1.14.14.74 | |
| MEDLINE | Find literature relating to 1.14.14.74 | |
| MetaCyc | 1.14.14.74 | |
| Rhea expert-curated reactions | 1.14.14.74 | |
| UniProtKB/Swiss-Prot |
| |
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