ENZYME entry: EC 1.14.14.74
| Accepted Name |
|---|
| albendazole monooxygenase (hydroxylating).
|
| Alternative Name(s) |
|---|
| CYP2J2. |
| Reaction catalysed |
|---|
| albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] |
| Comment(s) |
|---|
- CYP2J2 is a microsomal cytochrome P450 monooxygenase that catalyzes
the hydroxylation of the terminal carbon of the propylsulfanyl chain
in albendazole, a broad-spectrum anthelmintic used against
gastrointestinal nematodes and the larval stages of cestodes.
- Cf. EC 1.14.14.73.
|
| Cross-references |
|---|
| BRENDA | 1.14.14.74 |
| EC2PDB | 1.14.14.74 |
| ExplorEnz | 1.14.14.74 |
| PRIAM enzyme-specific profiles | 1.14.14.74 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.74 |
| IUBMB Enzyme Nomenclature | 1.14.14.74 |
| IntEnz | 1.14.14.74 |
| MEDLINE | Find literature relating to 1.14.14.74 |
| MetaCyc | 1.14.14.74 |
| Rhea expert-curated reactions | 1.14.14.74 |
| UniProtKB/Swiss-Prot |
|
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