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ENZYME entry: EC 1.14.14.74
Accepted Name |
albendazole monooxygenase (hydroxylating).
|
Alternative Name(s) |
CYP2J2. |
Reaction catalysed |
albendazole + O2 + reduced [NADPH--hemoprotein reductase] <=> H(+) + H2O + hydroxyalbendazole + oxidized [NADPH--hemoprotein reductase] |
Comment(s) |
- CYP2J2 is a microsomal cytochrome P450 monooxygenase that catalyzes
the hydroxylation of the terminal carbon of the propylsulfanyl chain
in albendazole, a broad-spectrum anthelmintic used against
gastrointestinal nematodes and the larval stages of cestodes.
- Cf. EC 1.14.14.73.
|
Cross-references |
BRENDA | 1.14.14.74 |
EC2PDB | 1.14.14.74 |
ExplorEnz | 1.14.14.74 |
PRIAM enzyme-specific profiles | 1.14.14.74 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.14.74 |
IUBMB Enzyme Nomenclature | 1.14.14.74 |
IntEnz | 1.14.14.74 |
MEDLINE | Find literature relating to 1.14.14.74 |
MetaCyc | 1.14.14.74 |
Rhea expert-curated reactions | 1.14.14.74 |
UniProtKB/Swiss-Prot |
|
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