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ENZYME entry: EC 1.14.14.74

Accepted Name
Albendazole monooxygenase (hydroxylating).
Alternative Name(s)
CYP2J2.
Reaction catalysed
Albendazole + [reduced NADPH--hemoprotein reductase] + O(2) <=> hydroxyalbendazole + [oxidized NADPH--hemoprotein reductase] + H(2)O
Comment(s)
  • CYP2J2 is a microsomal cytochrome P450 monooxygenase that catalyzes the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes.
  • Cf. EC 1.14.14.73.
Cross-references
BRENDA1.14.14.74
EC2PDB1.14.14.74
ExplorEnz1.14.14.74
PRIAM enzyme-specific profiles1.14.14.74
KEGG Ligand Database for Enzyme Nomenclature1.14.14.74
IUBMB Enzyme Nomenclature1.14.14.74
IntEnz1.14.14.74
MEDLINEFind literature relating to 1.14.14.74
MetaCyc1.14.14.74
UniProtKB/Swiss-Prot
P51589, CP2J2_HUMAN

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