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ENZYME

ENZYME entry: EC 1.14.14.77

Accepted Name
phenylacetonitrile alpha-monooxygenase
Alternative Name(s)
CYP3201B1
Reaction catalysed
O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] <=> (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase]
Comment(s)
  • The enzyme has been characterized from the cyanogenic millipede Chamberlinius hualienensis.
  • Unlike plant enzymes that can catalyze this reaction (EC 1.14.14.44), this enzyme cannot act on phenylacetaldehyde oximes.
  • It can accept (4-hydroxyphenyl)acetonitrile, (2-methylphenyl)acetonitrile, and (3-methylphenyl)acetonitrile as substrates at a lower rate.
Cross-references
BRENDA1.14.14.77
EC2PDB1.14.14.77
ExplorEnz1.14.14.77
PRIAM enzyme-specific profiles1.14.14.77
KEGG Ligand Database for Enzyme Nomenclature1.14.14.77
IUBMB Enzyme Nomenclature1.14.14.77
IntEnz1.14.14.77
MEDLINEFind literature relating to 1.14.14.77
MetaCyc1.14.14.77
Rhea expert-curated reactions1.14.14.77
UniProtKB/Swiss-Prot
A0A068Q609, C7124_PRUMU

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