ENZYME entry: EC 1.14.15.15
Accepted Name |
Cholestanetriol 26-monooxygenase.
|
Alternative Name(s) |
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase. |
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol hydroxylase. |
Cholestanetriol 26-hydroxylase. |
Cholesterol 27-hydroxylase. |
Cytochrome P450 27A1'. |
Sterol 26-hydroxylase. |
Sterol 27-hydroxylase. |
Vitamin D(3) 25-hydroxylase. |
Reaction catalysed |
5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol + 6 reduced adrenodoxin + 6 H(+) + 3 O(2) <=> (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestan-26-oate + 6 oxidized adrenodoxin + 4 H(2)O |
Cofactor(s) |
Heme-thiolate.
|
Comment(s) |
- Catalyzes the first three sterol side chain oxidations in bile acid
biosynthesis via the neutral (classic) pathway.
- Can also act on cholesterol, cholest-5-en-3-beta,7-alpha-diol,
7-alpha-hydroxycholest-4-en-3-one, and 5-beta-cholestane-3-alpha,7-
alpha-diol.
- The enzyme can also hydroxylate cholesterol at positions 24 and 25.
- The initial source of the electrons is NADPH, which transfers the
electrons to the adrenodoxin via EC 1.18.1.6.
- Formerly EC 1.14.13.15.
|
Cross-references |
PROSITE | PDOC00081 |
BRENDA | 1.14.15.15 |
EC2PDB | 1.14.15.15 |
ExplorEnz | 1.14.15.15 |
PRIAM enzyme-specific profiles | 1.14.15.15 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.15.15 |
IUBMB Enzyme Nomenclature | 1.14.15.15 |
IntEnz | 1.14.15.15 |
MEDLINE | Find literature relating to 1.14.15.15 |
MetaCyc | 1.14.15.15 |
Rhea expert-curated reactions | 1.14.15.15 |
UniProtKB/Swiss-Prot |
|
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