Home  |  Contact

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.15.16

Accepted Name
Vitamin D(3) 24-hydroxylase.
Alternative Name(s)
CYP24A1.
Reaction catalysed
  • Calcitriol + 2 reduced adrenodoxin + 2 H(+) + O(2) <=> calcitetrol + 2 oxidized adrenodoxin + H(2)O
  • Calcidiol + 2 reduced adrenodoxin + 2 H(+) + O(2) <=> secalciferol + 2 oxidized adrenodoxin + H(2)O
Cofactor(s)
Heme-thiolate.
Comment(s)
  • The enzyme can perform up to 6 rounds of hydroxylation of the substrate calcitriol leading to calcitroic acid.
  • The human enzyme also shows 23-hydroxylating activity leading to 1,25 dihydroxyvitamin D(3)-26,23-lactone as end product while the mouse and rat enzymes do not.
  • The initial source of the electrons is NADPH, which transfers the electrons to the adrenodoxin via EC 1.18.1.6.
  • Formerly EC 1.14.13.126 and EC 1.14.13.n4.
Cross-references
BRENDA1.14.15.16
EC2PDB1.14.15.16
ExplorEnz1.14.15.16
PRIAM enzyme-specific profiles1.14.15.16
KEGG Ligand Database for Enzyme Nomenclature1.14.15.16
IUBMB Enzyme Nomenclature1.14.15.16
IntEnz1.14.15.16
MEDLINEFind literature relating to 1.14.15.16
MetaCyc1.14.15.16
UniProtKB/Swiss-Prot
Q07973, CP24A_HUMAN;  Q64441, CP24A_MOUSE;  Q09128, CP24A_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.15.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-