ENZYME entry: EC 1.14.16.2
Accepted Name |
Tyrosine 3-monooxygenase.
|
Alternative Name(s) |
L-tyrosine hydroxylase. |
Tyrosine 3-hydroxylase. |
Tyrosine hydroxylase. |
Reaction catalysed |
L-tyrosine + tetrahydrobiopterin + O(2) <=> L-dopa + 4a-hydroxytetrahydrobiopterin |
Cofactor(s) |
Fe cation.
|
Comment(s) |
- Activated by phosphorylation, catalyzed by EC 2.7.11.27.
- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
dihydrobiopterin, both spontaneously and by the action of
EC 4.2.1.96.
- The 6,7-dihydrobiopterin can be enzymically reduced back to
tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
more stable compound 7,8-dihydrobiopterin.
|
Cross-references |
PROSITE | PDOC00316 |
BRENDA | 1.14.16.2 |
EC2PDB | 1.14.16.2 |
ExplorEnz | 1.14.16.2 |
PRIAM enzyme-specific profiles | 1.14.16.2 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.16.2 |
IUBMB Enzyme Nomenclature | 1.14.16.2 |
IntEnz | 1.14.16.2 |
MEDLINE | Find literature relating to 1.14.16.2 |
MetaCyc | 1.14.16.2 |
Rhea expert-curated reactions | 1.14.16.2 |
UniProtKB/Swiss-Prot |
O42091, TY3H_ANGAN; | P17289, TY3H_BOVIN; | A8X3V8, TY3H_CAEBR; |
P90986, TY3H_CAEEL; | Q76IQ3, TY3H_CANLF; | P18459, TY3H_DROME; |
P07101, TY3H_HUMAN; | P24529, TY3H_MOUSE; | A0A060X6Z0, TY3H_ONCMY; |
P11982, TY3H_PHASP; | P04177, TY3H_RAT; | O17446, TY3H_SCHMA; |
|
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