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ENZYME

ENZYME entry: EC 1.14.16.2

Accepted Name
tyrosine 3-monooxygenase
Alternative Name(s)
L-tyrosine hydroxylase
tyrosine 3-hydroxylase
tyrosine hydroxylase
Reaction catalysed
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa
Comment(s)
  • Activated by phosphorylation, catalyzed by EC 2.7.11.27.
  • The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96.
  • The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
Cross-references
BRENDA1.14.16.2
EC2PDB1.14.16.2
ExplorEnz1.14.16.2
PRIAM enzyme-specific profiles1.14.16.2
KEGG Ligand Database for Enzyme Nomenclature1.14.16.2
IUBMB Enzyme Nomenclature1.14.16.2
IntEnz1.14.16.2
MEDLINEFind literature relating to 1.14.16.2
MetaCyc1.14.16.2
Rhea expert-curated reactions1.14.16.2
UniProtKB/Swiss-Prot
O42091, TY3H_ANGANP17289, TY3H_BOVINA8X3V8, TY3H_CAEBR
P90986, TY3H_CAEELQ76IQ3, TY3H_CANLFP18459, TY3H_DROME
P07101, TY3H_HUMANP24529, TY3H_MOUSEA0A060X6Z0, TY3H_ONCMY
P11982, TY3H_PHASPP04177, TY3H_RATO17446, TY3H_SCHMA

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