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ENZYME entry: EC 1.14.19.21

Accepted Name
Cholesterol 7-desaturase.
Reaction catalysed
Cholesterol + O(2) + NAD(P)H <=> cholesta-5,7-dien-3-beta-ol + NAD(P)(+) + 2 H(2)O
Comment(s)
  • The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase.
  • In insects it participates in the the biosythesis of ecdysteroid hormones.
  • The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin.
  • The enzyme differs from regular desaturases, such as EC 1.14.19.20, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases.
Cross-references
BRENDA1.14.19.21
EC2PDB1.14.19.21
ExplorEnz1.14.19.21
PRIAM enzyme-specific profiles1.14.19.21
KEGG Ligand Database for Enzyme Nomenclature1.14.19.21
IUBMB Enzyme Nomenclature1.14.19.21
IntEnz1.14.19.21
MEDLINEFind literature relating to 1.14.19.21
MetaCyc1.14.19.21
Rhea expert-curated reactions1.14.19.21
UniProtKB/Swiss-Prot
Q17938, DAF36_CAEEL;  F7J186, NVD1_CIOIN;  F7J187, NVD2_CIOIN;  
Q1JUZ2, NVD_BOMMO;  Q6DHJ3, NVD_DANRE;  Q1JUZ1, NVD_DROME;  
F7J188, NVD_HEMPU;  F7J184, NVD_XENLA;  

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