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ENZYME

ENZYME entry: EC 1.14.19.21

Accepted Name
cholesterol 7-desaturase
Reaction catalysed
  • cholesterol + H(+) + NADPH + O2 = 7-dehydrocholesterol + 2 H2O + NADP(+)
  • cholesterol + H(+) + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD(+)
Comment(s)
  • The enzyme, characterized from several organisms including the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the ciliate Tetrahymena thermophila, is a Rieske oxygenase.
  • In insects it participates in the the biosythesis of ecdysteroid hormones.
  • The electrons are transferred from NAD(P)H via an electron transfer chain likely to include ferredoxin reductase and ferredoxin.
  • The enzyme differs from regular desaturases, such as EC 1.14.19.20, which are cytochrome b5-dependent and contain the three His-boxes that are typical to most desaturases.
Cross-references
BRENDA1.14.19.21
EC2PDB1.14.19.21
ExplorEnz1.14.19.21
PRIAM enzyme-specific profiles1.14.19.21
KEGG Ligand Database for Enzyme Nomenclature1.14.19.21
IUBMB Enzyme Nomenclature1.14.19.21
IntEnz1.14.19.21
MEDLINEFind literature relating to 1.14.19.21
MetaCyc1.14.19.21
Rhea expert-curated reactions1.14.19.21
UniProtKB/Swiss-Prot
Q17938, DAF36_CAEELF7J186, NVD1_CIOINF7J187, NVD2_CIOIN
Q1JUZ2, NVD_BOMMOQ6DHJ3, NVD_DANREQ1JUZ1, NVD_DROME
F7J188, NVD_HEMPUF7J184, NVD_XENLA

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