ENZYME entry: EC 1.14.19.60
| Accepted Name |
|---|
| 7-chloro-L-tryptophan 6-halogenase.
|
| Reaction catalysed |
|---|
| 7-chloro-L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6,7-dichloro-L-tryptophan + FAD + 2 H(2)O |
| Comment(s) |
|---|
- An FAD-dependent halogenase.
- The enzyme, characterized from the bacterium Kutzneria sp. 744, works
in tandem with EC 1.14.19.9 to generate 6,7-dichloro-L-tryptophan,
which is incorporated as a pyrroloindoline in the kutznerides family
of natural products.
- It has a 120-fold preference for 7-chloro-L-tryptophan over
L-tryptophan as substrate.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.60 |
| EC2PDB | 1.14.19.60 |
| ExplorEnz | 1.14.19.60 |
| PRIAM enzyme-specific profiles | 1.14.19.60 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.60 |
| IUBMB Enzyme Nomenclature | 1.14.19.60 |
| IntEnz | 1.14.19.60 |
| MEDLINE | Find literature relating to 1.14.19.60 |
| MetaCyc | 1.14.19.60 |
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