ENZYME entry: EC 1.14.19.60
Accepted Name |
7-chloro-L-tryptophan 6-halogenase.
|
Reaction catalysed |
7-chloro-L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6,7-dichloro-L-tryptophan + FAD + 2 H(2)O |
Comment(s) |
- An FAD-dependent halogenase.
- The enzyme, characterized from the bacterium Kutzneria sp. 744, works
in tandem with EC 1.14.19.9 to generate 6,7-dichloro-L-tryptophan,
which is incorporated as a pyrroloindoline in the kutznerides family
of natural products.
- It has a 120-fold preference for 7-chloro-L-tryptophan over
L-tryptophan as substrate.
|
Cross-references |
BRENDA | 1.14.19.60 |
EC2PDB | 1.14.19.60 |
ExplorEnz | 1.14.19.60 |
PRIAM enzyme-specific profiles | 1.14.19.60 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.60 |
IUBMB Enzyme Nomenclature | 1.14.19.60 |
IntEnz | 1.14.19.60 |
MEDLINE | Find literature relating to 1.14.19.60 |
MetaCyc | 1.14.19.60 |
Rhea expert-curated reactions | 1.14.19.60 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.14.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-