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ENZYME entry: EC 1.14.19.60

Accepted Name
7-chloro-L-tryptophan 6-halogenase.
Reaction catalysed
7-chloro-L-tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 6,7-dichloro-L-tryptophan + FAD + 2 H(2)O
Comment(s)
  • An FAD-dependent halogenase.
  • The enzyme, characterized from the bacterium Kutzneria sp. 744, works in tandem with EC 1.14.19.9 to generate 6,7-dichloro-L-tryptophan, which is incorporated as a pyrroloindoline in the kutznerides family of natural products.
  • It has a 120-fold preference for 7-chloro-L-tryptophan over L-tryptophan as substrate.
Cross-references
BRENDA1.14.19.60
EC2PDB1.14.19.60
ExplorEnz1.14.19.60
PRIAM enzyme-specific profiles1.14.19.60
KEGG Ligand Database for Enzyme Nomenclature1.14.19.60
IUBMB Enzyme Nomenclature1.14.19.60
IntEnz1.14.19.60
MEDLINEFind literature relating to 1.14.19.60
MetaCyc1.14.19.60

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