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ENZYME entry: EC 1.14.19.9

Accepted Name
tryptophan 7-halogenase.
Reaction catalysed
chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O
Comment(s)
  • A flavin-dependent halogenase.
  • The enzyme from the bacterium Lechevalieria aerocolonigenes catalyzes the initial step in the biosynthesis of rebeccamycin.
  • It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion.
  • The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate.
  • Also acts on bromide ion. cf. EC 1.14.19.58 and EC 1.14.19.59.
  • Formerly EC 1.14.14.7.
Cross-references
BRENDA1.14.19.9
EC2PDB1.14.19.9
ExplorEnz1.14.19.9
PRIAM enzyme-specific profiles1.14.19.9
KEGG Ligand Database for Enzyme Nomenclature1.14.19.9
IUBMB Enzyme Nomenclature1.14.19.9
IntEnz1.14.19.9
MEDLINEFind literature relating to 1.14.19.9
MetaCyc1.14.19.9
Rhea expert-curated reactions1.14.19.9
UniProtKB/Swiss-Prot
P95480, PRNA_PSEFL;  Q8KHZ8, REBH_LENAE;  

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