A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.19.9

Accepted Name
Tryptophan 7-halogenase.
Reaction catalysed
Tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 7-chloro-L-tryptophan + FAD + 2 H(2)O
Comment(s)
  • A flavin-dependent halogenase.
  • The enzyme from the bacterium Lechevalieria aerocolonigenes catalyzes the initial step in the biosynthesis of rebeccamycin.
  • It utilizes molecular oxygen to oxidize the FADH(2) cofactor, giving C4a-hydroperoxyflavin, which then reacts with chloride to produce a hypochlorite ion.
  • The latter reacts with an active site lysine to generate a chloramine, which chlorinates the substrate.
  • Also acts on bromide ion.
  • Cf. EC 1.14.19.58 and EC 1.14.19.59.
Cross-references
BRENDA1.14.19.9
EC2PDB1.14.19.9
ExplorEnz1.14.19.9
PRIAM enzyme-specific profiles1.14.19.9
KEGG Ligand Database for Enzyme Nomenclature1.14.19.9
IUBMB Enzyme Nomenclature1.14.19.9
IntEnz1.14.19.9
MEDLINEFind literature relating to 1.14.19.9
MetaCyc1.14.19.9
UniProtKB/Swiss-Prot
P95480, PRNA_PSEFL;  Q8KHZ8, REBH_NOCAE;  

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