ENZYME entry: EC 1.14.19.9
Accepted Name |
tryptophan 7-halogenase.
|
Reaction catalysed |
chloride + FADH2 + L-tryptophan + O2 <=> 7-chloro-L-tryptophan + FAD + 2 H2O |
Comment(s) |
- A flavin-dependent halogenase.
- The enzyme from the bacterium Lechevalieria aerocolonigenes catalyzes
the initial step in the biosynthesis of rebeccamycin.
- It utilizes molecular oxygen to oxidize the FADH2 cofactor, giving
C4a-hydroperoxyflavin, which then reacts with chloride to produce a
hypochlorite ion.
- The latter reacts with an active site lysine to generate a
chloramine, which chlorinates the substrate.
- Also acts on bromide ion. cf. EC 1.14.19.58 and EC 1.14.19.59.
- Formerly EC 1.14.14.7.
|
Cross-references |
BRENDA | 1.14.19.9 |
EC2PDB | 1.14.19.9 |
ExplorEnz | 1.14.19.9 |
PRIAM enzyme-specific profiles | 1.14.19.9 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.9 |
IUBMB Enzyme Nomenclature | 1.14.19.9 |
IntEnz | 1.14.19.9 |
MEDLINE | Find literature relating to 1.14.19.9 |
MetaCyc | 1.14.19.9 |
Rhea expert-curated reactions | 1.14.19.9 |
UniProtKB/Swiss-Prot |
|
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