ENZYME entry: EC 1.14.19.9
| Accepted Name |
|---|
| Tryptophan 7-halogenase.
|
| Reaction catalysed |
|---|
| Tryptophan + FADH(2) + chloride + O(2) + H(+) <=> 7-chloro-L-tryptophan + FAD + 2 H(2)O |
| Comment(s) |
|---|
- A flavin-dependent halogenase.
- The enzyme from the bacterium Lechevalieria aerocolonigenes catalyzes
the initial step in the biosynthesis of rebeccamycin.
- It utilizes molecular oxygen to oxidize the FADH(2) cofactor, giving
C4a-hydroperoxyflavin, which then reacts with chloride to produce a
hypochlorite ion.
- The latter reacts with an active site lysine to generate a
chloramine, which chlorinates the substrate.
- Also acts on bromide ion.
- Cf. EC 1.14.19.58 and EC 1.14.19.59.
|
| Cross-references |
|---|
| BRENDA | 1.14.19.9 |
| EC2PDB | 1.14.19.9 |
| ExplorEnz | 1.14.19.9 |
| PRIAM enzyme-specific profiles | 1.14.19.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.19.9 |
| IUBMB Enzyme Nomenclature | 1.14.19.9 |
| IntEnz | 1.14.19.9 |
| MEDLINE | Find literature relating to 1.14.19.9 |
| MetaCyc | 1.14.19.9 |
| Rhea expert-curated reactions | 1.14.19.9 |
| UniProtKB/Swiss-Prot |
|
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