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ENZYME entry: EC 1.14.20.11

Accepted Name
3-((Z)-2-isocyanoethenyl)-1H-indole synthase.
Reaction catalysed
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O(2) <=> 3-((Z)-2-isocyanoethenyl)-1H-indole + succinate + 2 CO(2) + H(2)O
Comment(s)
  • The enzyme, characterized from the cyanobacterium Fischerella ambigua UTEX 1903, participates in the biosynthesis of hapalindole-type alkaloids.
  • The enzyme catalyzes an Fe(2+), 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a cis C-C double bond.
  • Cf. EC 1.14.20.12.
Cross-references
BRENDA1.14.20.11
EC2PDB1.14.20.11
ExplorEnz1.14.20.11
PRIAM enzyme-specific profiles1.14.20.11
KEGG Ligand Database for Enzyme Nomenclature1.14.20.11
IUBMB Enzyme Nomenclature1.14.20.11
IntEnz1.14.20.11
MEDLINEFind literature relating to 1.14.20.11
MetaCyc1.14.20.11
Rhea expert-curated reactions1.14.20.11

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.20.-
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