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ENZYME entry: EC 1.14.20.12

Accepted Name
3-((E)-2-isocyanoethenyl)-1H-indole synthase.
Reaction catalysed
(2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + 2-oxoglutarate + O(2) <=> 3-((E)-2-isocyanoethenyl)-1H-indole + succinate + 2 CO(2) + H(2)O
Comment(s)
  • The enzyme has been characterized from an unidentified soil bacterium.
  • It catalyzes an Fe(2+), 2-oxoglutarate-dependent monooxygenation at C-3, which is followed by decarboxylation and dehydration, resulting in the generation of a trans C-C double bond.
  • Cf. EC 1.14.20.11.
Cross-references
BRENDA1.14.20.12
EC2PDB1.14.20.12
ExplorEnz1.14.20.12
PRIAM enzyme-specific profiles1.14.20.12
KEGG Ligand Database for Enzyme Nomenclature1.14.20.12
IUBMB Enzyme Nomenclature1.14.20.12
IntEnz1.14.20.12
MEDLINEFind literature relating to 1.14.20.12
MetaCyc1.14.20.12
Rhea expert-curated reactions1.14.20.12

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.20.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
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