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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.99.57

Accepted Name
Heme oxygenase (mycobilin-producing).
Reaction catalysed
  • Protoheme + 3 reduced acceptor + 3 O(2) <=> mycobilin a + Fe(2+) + 3 acceptor + 3 H(2)O
  • Protoheme + 3 reduced acceptor + 3 O(2) <=> mycobilin b + Fe(2+) + 3 acceptor + 3 H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization.
  • The enzyme binds two stacked protoheme molecules per monomer.
  • Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde; instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group.
  • EC 1.6.2.4.
Cross-references
BRENDA1.14.99.57
EC2PDB1.14.99.57
ExplorEnz1.14.99.57
PRIAM enzyme-specific profiles1.14.99.57
KEGG Ligand Database for Enzyme Nomenclature1.14.99.57
IUBMB Enzyme Nomenclature1.14.99.57
IntEnz1.14.99.57
MEDLINEFind literature relating to 1.14.99.57
MetaCyc1.14.99.57
UniProtKB/Swiss-Prot
P9WKH2, MHUD_MYCTO;  P9WKH3, MHUD_MYCTU;  

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