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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.14.99.57

Accepted Name

Heme oxygenase (mycobilin-producing).

Reaction catalysed

Protoheme + 3 reduced acceptor + 3 O(2) <=> mycobilin a + Fe(2+) + 3 acceptor + 3 H(2)O
Protoheme + 3 reduced acceptor + 3 O(2) <=> mycobilin b + Fe(2+) + 3 acceptor + 3 H(2)O

Comment(s)

The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization.
The enzyme binds two stacked protoheme molecules per monomer.
Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde; instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group.
EC 1.6.2.4.

Cross-references

BRENDA

EC2PDB

ExplorEnz

PRIAM enzyme-specific profiles

KEGG Ligand Database for Enzyme Nomenclature

IUBMB Enzyme Nomenclature

IntEnz

MEDLINE

MetaCyc

UniProtKB/Swiss-Prot

P9WKH2, MHUD_MYCTO;

P9WKH3, MHUD_MYCTU;

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-