A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.14.99.57
Accepted Name |
Heme oxygenase (mycobilin-producing).
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Reaction catalysed |
- Protoheme + 3 reduced acceptor + 3 O(2) <=> mycobilin a + Fe(2+) + 3 acceptor + 3 H(2)O
- Protoheme + 3 reduced acceptor + 3 O(2) <=> mycobilin b + Fe(2+) + 3 acceptor + 3 H(2)O
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Comment(s) |
- The enzyme, characterized from the bacterium Mycobacterium
tuberculosis, is involved in heme degradation and iron utilization.
- The enzyme binds two stacked protoheme molecules per monomer.
- Unlike the canonical heme oxygenases, the enzyme does not release
carbon monoxide or formaldehyde; instead, it forms unique products,
named mycobilins, that retain the alpha-meso-carbon at the ring
cleavage site as an aldehyde group.
- EC 1.6.2.4.
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Cross-references |
BRENDA | 1.14.99.57 |
EC2PDB | 1.14.99.57 |
ExplorEnz | 1.14.99.57 |
PRIAM enzyme-specific profiles | 1.14.99.57 |
KEGG Ligand Database for Enzyme Nomenclature | 1.14.99.57 |
IUBMB Enzyme Nomenclature | 1.14.99.57 |
IntEnz | 1.14.99.57 |
MEDLINE | Find literature relating to 1.14.99.57 |
MetaCyc | 1.14.99.57 |
UniProtKB/Swiss-Prot |
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