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ENZYME

ENZYME entry: EC 1.14.99.57

PURL: https://purl.expasy.org/enzyme/EC/1.14.99.57
Accepted Name
heme oxygenase (mycobilin-producing)
Reaction catalysed
  • heme b + 3 AH2 + 3 O2 + 2 H(+) = mycobilin a + Fe(2+) + 3 A + 3 H2O
  • heme b + 3 AH2 + 3 O2 + 2 H(+) = mycobilin b + Fe(2+) + 3 A + 3 H2O
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium tuberculosis, is involved in heme degradation and iron utilization.
  • The enzyme binds two stacked protoheme molecules per monomer.
  • Unlike the canonical heme oxygenases, the enzyme does not release carbon monoxide or formaldehyde; instead, it forms unique products, named mycobilins, that retain the alpha-meso-carbon at the ring cleavage site as an aldehyde group.
  • EC 1.6.2.4 can act as electron donor in vitro.
Cross-references
BRENDA1.14.99.57
EC2PDB1.14.99.57
ExplorEnz1.14.99.57
KEGG Ligand Database for Enzyme Nomenclature1.14.99.57
IUBMB Enzyme Nomenclature1.14.99.57
MEDLINEFind literature relating to 1.14.99.57
MetaCyc1.14.99.57
Rhea expert-curated reactions1.14.99.57
UniProtKB/Swiss-Prot
P9WKH2, MHUD_MYCTOP9WKH3, MHUD_MYCTU

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