Home  |  Contact

ENZYME entry: EC 1.14.99.68

Accepted Name
4-aminobenzoate N-oxygenase.
Reaction catalysed
4-aminobenzoate + reduced acceptor + 2 O(2) <=> 4-nitrobenzoate + acceptor + 2 H(2)O
Comment(s)
  • The enzyme, characterized from the bacterium Streptomyces thioluteus, catalyzes an early step in the biosynthesis of the antibiotic aureothin.
  • It contains a carboxylate-bridged binuclear non-heme iron cluster.
  • The native electron donor has not been identified, but is likely an iron-sulfur protein.
  • The reaction mechanism involves formation of an extremely stable peroxo intermediate that catalyzes three two-electron oxidations via a hydroxylamine and dihydroxylamine intermediates.
  • Cf. EC 1.14.99.67.
Cross-references
BRENDA1.14.99.68
EC2PDB1.14.99.68
ExplorEnz1.14.99.68
PRIAM enzyme-specific profiles1.14.99.68
KEGG Ligand Database for Enzyme Nomenclature1.14.99.68
IUBMB Enzyme Nomenclature1.14.99.68
IntEnz1.14.99.68
MEDLINEFind literature relating to 1.14.99.68
MetaCyc1.14.99.68
Rhea expert-curated reactions1.14.99.68

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.14.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-