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ENZYME entry: EC 1.16.1.10

Accepted Name
ferric-chelate reductase [NAD(P)H].
Alternative Name(s)
ferric reductase.
Reaction catalysed
  • 2 a Fe(II)-siderophore + H(+) + NAD(+) <=> 2 a Fe(III)-siderophore + NADH
  • 2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH
Comment(s)
  • The enzyme catalyzes the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron.
  • The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III).
  • Cf. EC 1.16.1.7 and EC 1.16.1.9.
Cross-references
BRENDA1.16.1.10
EC2PDB1.16.1.10
ExplorEnz1.16.1.10
PRIAM enzyme-specific profiles1.16.1.10
KEGG Ligand Database for Enzyme Nomenclature1.16.1.10
IUBMB Enzyme Nomenclature1.16.1.10
IntEnz1.16.1.10
MEDLINEFind literature relating to 1.16.1.10
MetaCyc1.16.1.10
Rhea expert-curated reactions1.16.1.10
UniProtKB/Swiss-Prot
O29428, FERCR_ARCFU

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