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ENZYME entry: EC 1.16.1.7

Accepted Name
Ferric-chelate reductase (NADH).
Alternative Name(s)
Ferric chelate reductase.
Iron chelate reductase.
NADH:Fe(3+) oxidoreductase.
NADH:Fe(3+)-EDTA reductase.
Reaction catalysed
2 Fe(II)-siderophore + NAD(+) + H(+) <=> 2 Fe(III)-siderophore + NADH
Cofactor(s)
FAD.
Comment(s)
  • The enzyme catalyzes the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron.
  • The plant enzyme is involved in the transport of iron across plant plasma membranes.
  • The enzyme from the bacterium Paracoccus denitrificans can also reduce chromate.
  • Cf. EC 1.16.1.9 and EC 1.16.1.10.
  • Formerly EC 1.6.99.13.
Cross-references
BRENDA1.16.1.7
EC2PDB1.16.1.7
ExplorEnz1.16.1.7
PRIAM enzyme-specific profiles1.16.1.7
KEGG Ligand Database for Enzyme Nomenclature1.16.1.7
IUBMB Enzyme Nomenclature1.16.1.7
IntEnz1.16.1.7
MEDLINEFind literature relating to 1.16.1.7
MetaCyc1.16.1.7
Rhea expert-curated reactions1.16.1.7
UniProtKB/Swiss-Prot
P84468, FERA_PARDE;  P84469, FERB_PARDE;  Q75CQ8, FRE8_ASHGO;  
Q12209, FRE8_YEAST;  P78588, FREL_CANAX;  Q9LMM2, FRO1_ARATH;  
P92949, FRO2_ARATH;  F4I4K7, FRO3_ARATH;  Q8W110, FRO4_ARATH;  
Q9FLW2, FRO5_ARATH;  Q8RWS6, FRO6_ARATH;  Q3KTM0, FRO7_ARATH;  
Q8VY13, FRO8_ARATH;  

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