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ENZYME

ENZYME entry: EC 1.16.1.9

Accepted Name
ferric-chelate reductase (NADPH)
Alternative Name(s)
ferric chelate reductase
iron chelate reductase
NADPH:Fe(3+)-EDTA reductase
Reaction catalysed
2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH
Comment(s)
  • The enzyme, which is widespread among bacteria, catalyzes the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron.
  • The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolyzed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine. cf. EC 1.16.1.7 and EC 1.16.1.10.
Cross-references
BRENDA1.16.1.9
EC2PDB1.16.1.9
ExplorEnz1.16.1.9
KEGG Ligand Database for Enzyme Nomenclature1.16.1.9
IUBMB Enzyme Nomenclature1.16.1.9
MEDLINEFind literature relating to 1.16.1.9
MetaCyc1.16.1.9
Rhea expert-curated reactions1.16.1.9
UniProtKB/Swiss-Prot
Q5A446, FRE1_CANALP32791, FRE1_YEASTP36033, FRE2_YEAST
Q08905, FRE3_YEASTP53746, FRE4_YEASTQ08908, FRE5_YEAST
Q12473, FRE6_YEASTA6ZN61, FRE7_YEAS7Q12333, FRE7_YEAST
Q04800, FRP1_SCHPOO94727, FRP2_SCHPOQ2U6T7, KAP2_ASPOR
Q46871, YQJH_ECOLI

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