ENZYME entry: EC 1.16.1.9
Accepted Name |
Ferric-chelate reductase (NADPH).
|
Alternative Name(s) |
Ferric chelate reductase. |
Iron chelate reductase. |
NADPH:Fe(3+)-EDTA reductase. |
Reaction catalysed |
2 Fe(II)-siderophore + NADP(+) + H(+) <=> 2 Fe(III)-siderophore + NADPH |
Cofactor(s) |
FAD.
|
Comment(s) |
- The enzyme, which is widespread among bacteria, catalyzes the
reduction of ferric iron bound to a variety of iron chelators
(siderophores), including ferric triscatecholates and ferric
dicitrate, resulting in the release of ferrous iron.
- The enzyme from the bacterium Escherichia coli has the highest
efficiency with the hydrolyzed ferric enterobactin complex ferric
N-(2,3-dihydroxybenzoyl)-L-serine.
- Cf. EC 1.16.1.7 and EC 1.16.1.10.
|
Cross-references |
BRENDA | 1.16.1.9 |
EC2PDB | 1.16.1.9 |
ExplorEnz | 1.16.1.9 |
PRIAM enzyme-specific profiles | 1.16.1.9 |
KEGG Ligand Database for Enzyme Nomenclature | 1.16.1.9 |
IUBMB Enzyme Nomenclature | 1.16.1.9 |
IntEnz | 1.16.1.9 |
MEDLINE | Find literature relating to 1.16.1.9 |
MetaCyc | 1.16.1.9 |
UniProtKB/Swiss-Prot |
Q5A446, FRE1_CANAL; | P32791, FRE1_YEAST; | P36033, FRE2_YEAST; |
Q08905, FRE3_YEAST; | P53746, FRE4_YEAST; | Q08908, FRE5_YEAST; |
Q12473, FRE6_YEAST; | A6ZN61, FRE7_YEAS7; | Q12333, FRE7_YEAST; |
Q04800, FRP1_SCHPO; | O94727, FRP2_SCHPO; | Q687X5, STEA4_HUMAN; |
Q923B6, STEA4_MOUSE; | Q4V8K1, STEA4_RAT; | Q46871, YQJH_ECOLI; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.16.1.-
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