ENZYME entry: EC 1.16.1.9
| Accepted Name |
|---|
| Ferric-chelate reductase (NADPH).
|
| Alternative Name(s) |
|---|
| Ferric chelate reductase. |
| Iron chelate reductase. |
| NADPH:Fe(3+)-EDTA reductase. |
| Reaction catalysed |
|---|
| 2 Fe(II)-siderophore + NADP(+) + H(+) <=> 2 Fe(III)-siderophore + NADPH |
| Cofactor(s) |
|---|
| FAD.
|
| Comment(s) |
|---|
- The enzyme, which is widespread among bacteria, catalyzes the
reduction of ferric iron bound to a variety of iron chelators
(siderophores), including ferric triscatecholates and ferric
dicitrate, resulting in the release of ferrous iron.
- The enzyme from the bacterium Escherichia coli has the highest
efficiency with the hydrolyzed ferric enterobactin complex ferric
N-(2,3-dihydroxybenzoyl)-L-serine.
- Cf. EC 1.16.1.7 and EC 1.16.1.10.
|
| Cross-references |
|---|
| BRENDA | 1.16.1.9 |
| EC2PDB | 1.16.1.9 |
| ExplorEnz | 1.16.1.9 |
| PRIAM enzyme-specific profiles | 1.16.1.9 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.16.1.9 |
| IUBMB Enzyme Nomenclature | 1.16.1.9 |
| IntEnz | 1.16.1.9 |
| MEDLINE | Find literature relating to 1.16.1.9 |
| MetaCyc | 1.16.1.9 |
| UniProtKB/Swiss-Prot |
| Q5A446, FRE1_CANAL; | P32791, FRE1_YEAST; | P36033, FRE2_YEAST; |
| Q08905, FRE3_YEAST; | P53746, FRE4_YEAST; | Q08908, FRE5_YEAST; |
| Q12473, FRE6_YEAST; | A6ZN61, FRE7_YEAS7; | Q12333, FRE7_YEAST; |
| Q04800, FRP1_SCHPO; | O94727, FRP2_SCHPO; | Q46871, YQJH_ECOLI; |
|
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