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ENZYME entry: EC 1.16.1.9

Accepted Name
ferric-chelate reductase (NADPH).
Alternative Name(s)
ferric chelate reductase.
iron chelate reductase.
NADPH:Fe(3+)-EDTA reductase.
Reaction catalysed
2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH
Comment(s)
  • The enzyme, which is widespread among bacteria, catalyzes the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron.
  • The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolyzed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine.
  • Cf. EC 1.16.1.7 and EC 1.16.1.10.
Cross-references
BRENDA1.16.1.9
EC2PDB1.16.1.9
ExplorEnz1.16.1.9
PRIAM enzyme-specific profiles1.16.1.9
KEGG Ligand Database for Enzyme Nomenclature1.16.1.9
IUBMB Enzyme Nomenclature1.16.1.9
IntEnz1.16.1.9
MEDLINEFind literature relating to 1.16.1.9
MetaCyc1.16.1.9
Rhea expert-curated reactions1.16.1.9
UniProtKB/Swiss-Prot
Q5A446, FRE1_CANAL;  P32791, FRE1_YEAST;  P36033, FRE2_YEAST;  
Q08905, FRE3_YEAST;  P53746, FRE4_YEAST;  Q08908, FRE5_YEAST;  
Q12473, FRE6_YEAST;  A6ZN61, FRE7_YEAS7;  Q12333, FRE7_YEAST;  
Q04800, FRP1_SCHPO;  O94727, FRP2_SCHPO;  Q687X5, STEA4_HUMAN;  
Q923B6, STEA4_MOUSE;  Q4V8K1, STEA4_RAT;  Q46871, YQJH_ECOLI;  

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