Expasy logo

ENZYME

ENZYME entry: EC 1.16.1.9

Accepted Name
ferric-chelate reductase (NADPH)
Alternative Name(s)
ferric chelate reductase
iron chelate reductase
NADPH:Fe(3+)-EDTA reductase
Reaction catalysed
2 a Fe(II)-siderophore + H(+) + NADP(+) <=> 2 a Fe(III)-siderophore + NADPH
Comment(s)
  • The enzyme, which is widespread among bacteria, catalyzes the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron.
  • The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolyzed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine. cf. EC 1.16.1.7 and EC 1.16.1.10.
Cross-references
BRENDA1.16.1.9
EC2PDB1.16.1.9
ExplorEnz1.16.1.9
PRIAM enzyme-specific profiles1.16.1.9
KEGG Ligand Database for Enzyme Nomenclature1.16.1.9
IUBMB Enzyme Nomenclature1.16.1.9
IntEnz1.16.1.9
MEDLINEFind literature relating to 1.16.1.9
MetaCyc1.16.1.9
Rhea expert-curated reactions1.16.1.9
UniProtKB/Swiss-Prot
Q5A446, FRE1_CANALP32791, FRE1_YEASTP36033, FRE2_YEAST
Q08905, FRE3_YEASTP53746, FRE4_YEASTQ08908, FRE5_YEAST
Q12473, FRE6_YEASTA6ZN61, FRE7_YEAS7Q12333, FRE7_YEAST
Q04800, FRP1_SCHPOO94727, FRP2_SCHPOQ687X5, STEA4_HUMAN
Q923B6, STEA4_MOUSEQ4V8K1, STEA4_RATQ46871, YQJH_ECOLI

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.16.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-