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ENZYME entry: EC 1.17.4.5

Accepted Name
vitamin-K-epoxide reductase (warfarin-insensitive).
Alternative Name(s)
vitamin K 2,3-epoxide reductase.
Reaction catalysed
3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol <=> 1,4-dithiothreitol + 2,3-epoxyphylloquinone
Comment(s)
  • Vitamin K 2,3-epoxide is reduced to 3-hydroxy- (and 2-hydroxy-) vitamin K by 1,4-dithiothreitol, which is oxidized to a disulfide.
  • Not inhibited by warfarin (cf. EC 1.17.4.4).
  • Formerly EC 1.1.4.2.
Cross-references
BRENDA1.17.4.5
EC2PDB1.17.4.5
ExplorEnz1.17.4.5
PRIAM enzyme-specific profiles1.17.4.5
KEGG Ligand Database for Enzyme Nomenclature1.17.4.5
IUBMB Enzyme Nomenclature1.17.4.5
IntEnz1.17.4.5
MEDLINEFind literature relating to 1.17.4.5
MetaCyc1.17.4.5
Rhea expert-curated reactions1.17.4.5

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-