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ENZYME

ENZYME entry: EC 1.17.4.4

Accepted Name
vitamin-K-epoxide reductase (warfarin-sensitive)
Alternative Name(s)
phylloquinone epoxide reductase
vitamin K1 epoxide reductase
Reaction catalysed
  • [protein]-disulfide + H2O + phylloquinone <=> 2,3-epoxyphylloquinone + [protein]-dithiol
  • [protein]-disulfide + phylloquinol <=> [protein]-dithiol + phylloquinone
Comment(s)
  • The enzyme catalyzes the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, back to its phylloquinol active form.
  • The enzyme forms a tight complex with EC 5.3.4.1, which transfers the required electrons from newly-synthesized proteins by catalyzing the formation of disulfide bridges.
  • The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2).
  • Inhibited strongly by (S)-warfarin and ferulenol.
  • Formerly EC 1.1.4.1.
Cross-references
BRENDA1.17.4.4
EC2PDB1.17.4.4
ExplorEnz1.17.4.4
PRIAM enzyme-specific profiles1.17.4.4
KEGG Ligand Database for Enzyme Nomenclature1.17.4.4
IUBMB Enzyme Nomenclature1.17.4.4
IntEnz1.17.4.4
MEDLINEFind literature relating to 1.17.4.4
MetaCyc1.17.4.4
Rhea expert-curated reactions1.17.4.4
UniProtKB/Swiss-Prot
Q6B4J2, VKOR1_BOVINQ9BQB6, VKOR1_HUMANQ9CRC0, VKOR1_MOUSE
Q6TEK4, VKOR1_RATQ8N0U8, VKORL_HUMANQ6TEK5, VKORL_MOUSE
Q6TEK3, VKORL_RATQ6TEK8, VKORL_TAKRU

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