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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.17.4.4

Accepted Name
Vitamin-K-epoxide reductase (warfarin-sensitive).
Alternative Name(s)
Phylloquinone epoxide reductase.
Vitamin K1 epoxide reductase.
Reaction catalysed
  • Phylloquinone + a protein with a disulfide bond + H(2)O <=> 2,3-epoxyphylloquinone + a protein with reduced L-cysteine residues
  • Phylloquinol + a protein with a disulfide bond <=> phylloquinone + a protein with reduced L-cysteine residues
Comment(s)
  • The enzyme catalyzes the reduction of vitamin K 2,3-epoxide, which is formed by the activity of EC 4.1.1.90, back to its phylloquinol active form.
  • The enzyme forms a tight complex with EC 5.3.4.1, which transfers the required electrons from newly-synthesized proteins by catalyzing the formation of disulfide bridges.
  • The enzyme acts on the epoxide forms of both phylloquinone (vitamin K1) and menaquinone (vitamin K2).
  • Inhibited strongly by (S)-warfarin and ferulenol.
  • Formerly EC 1.1.4.1.
Cross-references
BRENDA1.17.4.4
EC2PDB1.17.4.4
ExplorEnz1.17.4.4
PRIAM enzyme-specific profiles1.17.4.4
KEGG Ligand Database for Enzyme Nomenclature1.17.4.4
IUBMB Enzyme Nomenclature1.17.4.4
IntEnz1.17.4.4
MEDLINEFind literature relating to 1.17.4.4
MetaCyc1.17.4.4
UniProtKB/Swiss-Prot
Q6B4J2, VKOR1_BOVIN;  Q9BQB6, VKOR1_HUMAN;  Q9CRC0, VKOR1_MOUSE;  
Q6TEK4, VKOR1_RAT;  Q8N0U8, VKORL_HUMAN;  Q6TEK5, VKORL_MOUSE;  
Q6TEK3, VKORL_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.17.-.-
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