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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
L-2-aminoadipate reductase.
Alternative Name(s)
Alpha-aminoadipate reductase.
Reaction catalysed
(S)-2-amino-6-oxohexanoate + NADP(+) + AMP + diphosphate <=> L-2-aminoadipate + NADPH + ATP
  • This enzyme, characterized from the yeast Saccharomyces cerevisiae, catalyzes the reduction of L-2-aminoadipate to (S)-2-amino-6- oxohexanoate during L-lysine biosynthesis.
  • An adenylation domain activates the substrate at the expense of ATP hydrolysis, and forms L-2-aminoadipate adenylate, which is attached to a peptidyl-carrier protein (PCP) domain.
  • Binding of NADPH results in reductive cleavage of the acyl-S-enzyme intermediate, releasing (S)-2-amino-6-oxohexanoate.
  • Different from EC which catalyzes a similar transformation in the opposite direction without ATP hydrolysis.
PRIAM enzyme-specific profiles1.2.1.95
KEGG Ligand Database for Enzyme Nomenclature1.2.1.95
IUBMB Enzyme Nomenclature1.2.1.95
MEDLINEFind literature relating to
O74298, LYS2_PENCH;  P40976, LYS2_SCHPO;  P07702, LYS2_YEAST;  

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