Accepted Name |
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).
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Alternative Name(s) |
2-oxoisocaproate dehydrogenase. |
2-oxoisovalerate (lipoate) dehydrogenase. |
3-methyl-2-oxobutanoate dehydrogenase (lipoamide). |
Alpha-keto-alpha-methylvalerate dehydrogenase. |
Alpha-ketoisocaproate dehydrogenase. |
Alpha-ketoisocaproic dehydrogenase. |
Alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase. |
Alpha-ketoisovalerate dehydrogenase. |
Alpha-oxoisocaproate dehydrogenase. |
BCKDH. |
BCOAD. |
Branched chain keto acid dehydrogenase. |
Branched-chain (-2-oxoacid) dehydrogenase (BCD). |
Branched-chain 2-keto acid dehydrogenase. |
Branched-chain 2-oxo acid dehydrogenase. |
Branched-chain alpha-keto acid dehydrogenase. |
Branched-chain alpha-oxo acid dehydrogenase. |
Branched-chain keto acid dehydrogenase. |
Branched-chain ketoacid dehydrogenase. |
Dehydrogenase, 2-oxoisovalerate (lipoate). |
Reaction catalysed |
3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] lipoyllysine <=> [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + CO(2) |
Cofactor(s) |
Thiamine diphosphate.
|
Comment(s) |
- It acts not only on 3-methyl-2-oxobutanaoate, but also on 4-methyl-2-
oxopentanoate and (S)-3-methyl-2-oxopentanoate, so that it acts on
the 2-oxo acids that derive from the action of transaminases on
valine, leucine and isoleucine.
- It is a component of the multienzyme 3-methyl-2-oxobutanoate
dehydrogenase complex in which multiple copies of it are bound to a
core of molecules of EC 2.3.1.168, which also binds multiple copies
of EC 1.8.1.4.
- It does not act on free lipoamide or lipoyllysine, but only on the
lipoyllysine residue in EC 2.3.1.168.
- Formerly EC 1.2.4.3.
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Cross-references |
BRENDA | 1.2.4.4 |
EC2PDB | 1.2.4.4 |
ExplorEnz | 1.2.4.4 |
PRIAM enzyme-specific profiles | 1.2.4.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.2.4.4 |
IUBMB Enzyme Nomenclature | 1.2.4.4 |
IntEnz | 1.2.4.4 |
MEDLINE | Find literature relating to 1.2.4.4 |
MetaCyc | 1.2.4.4 |
Rhea expert-curated reactions | 1.2.4.4 |
UniProtKB/Swiss-Prot |
P9WIS2, BKDA_MYCTO; | P9WIS3, BKDA_MYCTU; | P9WIS0, BKDB_MYCTO; |
P9WIS1, BKDB_MYCTU; | Q9LPL5, ODBA1_ARATH; | Q84JL2, ODBA2_ARATH; |
P37940, ODBA_BACSU; | P11178, ODBA_BOVIN; | O45924, ODBA_CAEEL; |
Q54M22, ODBA_DICDI; | P12694, ODBA_HUMAN; | Q8HXY4, ODBA_MACFA; |
P50136, ODBA_MOUSE; | A5A6H9, ODBA_PANTR; | Q9I1M2, ODBA_PSEAE; |
P09060, ODBA_PSEPU; | P11960, ODBA_RAT; | Q72GU1, ODBA_THET2; |
Q5SLR4, ODBA_THET8; | Q9SAV3, ODBB1_ARATH; | Q9LDY2, ODBB2_ARATH; |
P37941, ODBB_BACSU; | P21839, ODBB_BOVIN; | P9WF02, ODBB_CHATD; |
Q55FN7, ODBB_DICDI; | P21953, ODBB_HUMAN; | Q6P3A8, ODBB_MOUSE; |
Q9I1M1, ODBB_PSEAE; | P09061, ODBB_PSEPU; | P35738, ODBB_RAT; |
Q72GU2, ODBB_THET2; | Q5SLR3, ODBB_THET8; |
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