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ENZYME

ENZYME entry: EC 2.3.1.168

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.168
Accepted Name
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase
Alternative Name(s)
dihydrolipoyl transacylase
Reaction catalysed
N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA
Comment(s)
  • A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC 1.2.4.4 and EC 1.8.1.4.
  • The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC 1.2.4.4, and the only observed direction catalyzed by EC 2.3.1.168 is that where this 2-methylpropanoyl is passed to coenzyme A.
  • In addition to the 2-methylpropanoyl group, formed when EC 1.2.4.4 acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC 1.2.4.4 acts on the oxo acids corresponding with leucine and isoleucine.
Cross-references
BRENDA2.3.1.168
EC2PDB2.3.1.168
ExplorEnz2.3.1.168
KEGG Ligand Database for Enzyme Nomenclature2.3.1.168
IUBMB Enzyme Nomenclature2.3.1.168
MEDLINEFind literature relating to 2.3.1.168
MetaCyc2.3.1.168
Rhea expert-curated reactions2.3.1.168
UniProtKB/Swiss-Prot
O06159, BKDC_MYCTUQ9M7Z1, ODB2_ARATHP37942, ODB2_BACSU
P11181, ODB2_BOVINQ23571, ODB2_CAEELP11182, ODB2_HUMAN
P53395, ODB2_MOUSEQ9I1M0, ODB2_PSEAEP09062, ODB2_PSEPU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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