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ENZYME entry: EC

Accepted Name
dihydrolipoyllysine-residue (2-methylpropanoyl)transferase.
Alternative Name(s)
dihydrolipoyl transacylase.
Reaction catalysed
(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2-methylpropanoyl-CoA <=> (R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysyl-[protein] + CoA
  • A multimer (24-mer) of this enzyme forms the core of the multienzyme 3-methyl-2-oxobutanoate dehydrogenase complex, and binds tightly both EC and EC
  • The lipoyl group of this enzyme is reductively 2-methylpropanoylated by EC, and the only observed direction catalyzed by EC is that where this 2-methylpropanoyl is passed to coenzyme A.
  • In addition to the 2-methylpropanoyl group, formed when EC acts on the oxoacid that corresponds with valine, this enzyme also transfers the 3-methylbutanoyl and S-2-methylbutanoyl groups, donated to it when EC acts on the oxo acids corresponding with leucine and isoleucine.
PRIAM enzyme-specific profiles2.3.1.168
KEGG Ligand Database for Enzyme Nomenclature2.3.1.168
IUBMB Enzyme Nomenclature2.3.1.168
MEDLINEFind literature relating to
Rhea expert-curated reactions2.3.1.168
O06159, BKDC_MYCTU;  Q9M7Z1, ODB2_ARATH;  P37942, ODB2_BACSU;  
P11181, ODB2_BOVIN;  Q23571, ODB2_CAEEL;  P11182, ODB2_HUMAN;  
P53395, ODB2_MOUSE;  Q9I1M0, ODB2_PSEAE;  P09062, ODB2_PSEPU;  

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