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ENZYME

ENZYME entry: EC 1.8.1.4

PURL: https://purl.expasy.org/enzyme/EC/1.8.1.4
Accepted Name
dihydrolipoyl dehydrogenase
Alternative Name(s)
dehydrolipoate dehydrogenase
diaphorase
dihydrolipoamide dehydrogenase
dihydrolipoic dehydrogenase
dihydrothioctic dehydrogenase
E3 component of alpha-ketoacid dehydrogenase complexes
glycine-cleavage system L-protein
LDP-Glc
LDP-Val
lipoamide dehydrogenase (NADH)
lipoamide oxidoreductase (NADH)
lipoamide reductase
lipoamide reductase (NADH)
lipoate dehydrogenase
lipoic acid dehydrogenase
lipoyl dehydrogenase
L-protein
Reaction catalysed
N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)
Comment(s)
  • A component of the multienzyme 2-oxo-acid dehydrogenase complexes.
  • In the pyruvate dehydrogenase complex, it binds to the core of EC 2.3.1.12 and catalyzes oxidation of its dihydrolipoyl groups.
  • It plays a similar role in the oxoglutarate and 3-methyl-2- oxobutanoate dehydrogenase complexes.
  • Another substrate is the dihydrolipoyl group in the H-protein of the glycine-cleavage system, in which it acts, together with EC 1.4.4.2 and EC 2.1.2.10 to break down glycine.
  • It can also use free dihydrolipoate, dihydrolipoamide or dihydrolipoyllysine as substrate.
  • Was first shown to catalyze the oxidation of NADH by methylene blue; this activity was called diaphorase.
  • The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.
  • Formerly EC 1.6.4.3.
Cross-references
BRENDA1.8.1.4
EC2PDB1.8.1.4
ExplorEnz1.8.1.4
KEGG Ligand Database for Enzyme Nomenclature1.8.1.4
IUBMB Enzyme Nomenclature1.8.1.4
MEDLINEFind literature relating to 1.8.1.4
MetaCyc1.8.1.4
Rhea expert-curated reactions1.8.1.4
UniProtKB/Swiss-Prot
Q9M5K3, DLDH1_ARATHP21880, DLDH1_BACSUP11959, DLDH1_GEOSE
Q9I1L9, DLDH1_PSEAEP09063, DLDH1_PSEPUQ9M5K2, DLDH2_ARATH
P54533, DLDH2_BACSUQ5UYG6, DLDH2_HALMAQ9I3D1, DLDH2_PSEAE
P31052, DLDH2_PSEPUO34324, DLDH3_BACSUQ5UWH2, DLDH3_HALMA
Q9HUY1, DLDH3_PSEAEP31046, DLDH3_PSEPUP35484, DLDH_ACHLA
P18925, DLDH_AZOVIF1N206, DLDH_BOVINP57303, DLDH_BUCAI
Q8K9T7, DLDH_BUCAPQ89AQ8, DLDH_BUCBPO17953, DLDH_CAEEL
P49819, DLDH_CANLFG0SB20, DLDH_CHATDQ9PJI3, DLDH_CHLMU
O50311, DLDH_CHLP8Q9Z773, DLDH_CHLPNQ8KCW2, DLDH_CHLTE
O84561, DLDH_CHLTRQ8NTE1, DLDH_CORGLQ8CIZ7, DLDH_CRIGR
P52992, DLDH_CUPNHQ54EW8, DLDH_DICDIP0A9P2, DLDH_ECO57
P0A9P1, DLDH_ECOL6P0A9P0, DLDH_ECOLIP43784, DLDH_HAEIN
Q9HN74, DLDH_HALSAQ04829, DLDH_HALVDP09622, DLDH_HUMAN
P80647, DLDH_HYMDIQ60HG3, DLDH_MACFAO18480, DLDH_MANSE
Q811C4, DLDH_MESAUO08749, DLDH_MOUSEP66005, DLDH_MYCBO
P47513, DLDH_MYCGEQ50068, DLDH_MYCLEP75393, DLDH_MYCPN
P9WHH8, DLDH_MYCTOP9WHH9, DLDH_MYCTUP31023, DLDH_PEA
P09623, DLDH_PIGQ5R4B1, DLDH_PONABP84545, DLDH_POPEU
P14218, DLDH_PSEFLQ6P6R2, DLDH_RATO05940, DLDH_RHIEC
P95596, DLDH_RHOCAO00087, DLDH_SCHPOP0A9P3, DLDH_SHIFL
P80503, DLDH_SOLTUQ5HGY8, DLDH_STAACP0A0E6, DLDH_STAAM
P99084, DLDH_STAANQ6GHY9, DLDH_STAARQ6GAB8, DLDH_STAAS
P0A0E8, DLDH_STAAUP0A0E7, DLDH_STAAWP72740, DLDH_SYNY3
P85207, DLDH_THESSQ04933, DLDH_TRYBBP90597, DLDH_TRYCR
Q9KPF6, DLDH_VIBCHO50286, DLDH_VIBPAP09624, DLDH_YEAST
P50970, DLDH_ZYMMOA8MS68, PLPD1_ARATHF4JLP5, PLPD2_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.8.-.-
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