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ENZYME entry: EC 1.2.7.3

Accepted Name
2-oxoglutarate synthase.
Alternative Name(s)
2-ketoglutarate ferredoxin oxidoreductase.
2-oxoglutarate ferredoxin oxidoreductase.
Alpha-ketoglutarate synthase.
Alpha-ketoglutarate-ferredoxin oxidoreductase.
KGOR.
Reaction catalysed
2-oxoglutarate + CoA + 2 oxidized ferredoxin <=> succinyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+)
Cofactor(s)
Iron-sulfur; Thiamine diphosphate.
Comment(s)
  • Highly specific for 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.7.
  • Formerly EC 1.2.7.9.
Cross-references
BRENDA1.2.7.3
EC2PDB1.2.7.3
ExplorEnz1.2.7.3
PRIAM enzyme-specific profiles1.2.7.3
KEGG Ligand Database for Enzyme Nomenclature1.2.7.3
IUBMB Enzyme Nomenclature1.2.7.3
IntEnz1.2.7.3
MEDLINEFind literature relating to 1.2.7.3
MetaCyc1.2.7.3
Rhea expert-curated reactions1.2.7.3
UniProtKB/Swiss-Prot
O29781, KORA_ARCFU;  Q57724, KORA_METJA;  O27112, KORA_METTH;  
P80904, KORA_METTM;  O53182, KORA_MYCTU;  O29782, KORB_ARCFU;  
Q57957, KORB_METJA;  O27113, KORB_METTH;  P80905, KORB_METTM;  
O53181, KORB_MYCTU;  O29779, KORC_ARCFU;  Q57956, KORC_METJA;  
O27114, KORC_METTH;  P80906, KORC_METTM;  

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