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ENZYME

ENZYME entry: EC 1.2.7.7

Accepted Name
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
Alternative Name(s)
2-ketoisovalerate ferredoxin reductase
2-oxoisovalerate ferredoxin reductase
3-methyl-2-oxobutanoate synthase (ferredoxin)
branched-chain ketoacid ferredoxin reductase
branched-chain oxo acid ferredoxin reductase
ketoisovalerate ferredoxin reductase
ketoisovalerate oxidoreductase
keto-valine-ferredoxin oxidoreductase
VOR
Reaction catalysed
3-methyl-2-oxobutanoate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = 2-methylpropanoyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme is CoA-dependent and contains thiamine diphosphate and iron-sulfur clusters.
  • Preferentially utilizes 2-oxo-acid derivatives of branched chain amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo- pentanoate, and 2-oxobutanoate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that reversibly catalyze the oxidative decarboxylation of different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.1 and EC 1.2.7.3.
Cross-references
BRENDA1.2.7.7
EC2PDB1.2.7.7
ExplorEnz1.2.7.7
PRIAM enzyme-specific profiles1.2.7.7
KEGG Ligand Database for Enzyme Nomenclature1.2.7.7
IUBMB Enzyme Nomenclature1.2.7.7
IntEnz1.2.7.7
MEDLINEFind literature relating to 1.2.7.7
MetaCyc1.2.7.7
Rhea expert-curated reactions1.2.7.7
UniProtKB/Swiss-Prot
Q9UYY9, PORC_PYRABP84819, PORC_PYRENQ51799, PORC_PYRFU
O58411, PORC_PYRHOQ5JIK2, PORC_THEKOP84820, PORC_THELN
O26801, VORA_METTHQ9UYZ1, VORA_PYRABQ51801, VORA_PYRFU
O58413, VORA_PYRHOO26800, VORB_METTHP80908, VORB_METTM
Q9UYZ2, VORB_PYRABQ51802, VORB_PYRFUO58414, VORB_PYRHO
O26799, VORC_METTHP80909, VORC_METTMQ9UYZ0, VORD_PYRAB
Q51800, VORD_PYRFUO58412, VORD_PYRHO

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