Accepted Name |
3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
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Alternative Name(s) |
2-ketoisovalerate ferredoxin reductase. |
2-oxoisovalerate ferredoxin reductase. |
3-methyl-2-oxobutanoate synthase (ferredoxin). |
Branched-chain ketoacid ferredoxin reductase. |
Branched-chain oxo acid ferredoxin reductase. |
Keto-valine-ferredoxin oxidoreductase. |
Ketoisovalerate ferredoxin reductase. |
Ketoisovalerate oxidoreductase. |
VOR. |
Reaction catalysed |
3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin <=> S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+) |
Cofactor(s) |
Iron-sulfur; Tungstopterin.
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Comment(s) |
- The enzyme is CoA-dependent and contains thiamine diphosphate and
iron-sulfur clusters.
- Preferentially utilizes 2-oxo-acid derivatives of branched chain
amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-
pentanoate, and 2-oxobutanoate.
- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of
enzymes that reversibly catalyze the oxidative decarboxylation of
different 2-oxoacids to form their CoA derivatives, and are
differentiated based on their substrate specificity.
- For examples of other members of this family, see EC 1.2.7.1 and
EC 1.2.7.3.
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Cross-references |
BRENDA | 1.2.7.7 |
EC2PDB | 1.2.7.7 |
ExplorEnz | 1.2.7.7 |
PRIAM enzyme-specific profiles | 1.2.7.7 |
KEGG Ligand Database for Enzyme Nomenclature | 1.2.7.7 |
IUBMB Enzyme Nomenclature | 1.2.7.7 |
IntEnz | 1.2.7.7 |
MEDLINE | Find literature relating to 1.2.7.7 |
MetaCyc | 1.2.7.7 |
Rhea expert-curated reactions | 1.2.7.7 |
UniProtKB/Swiss-Prot |
Q9UYY9, PORC_PYRAB; | P84819, PORC_PYREN; | Q51799, PORC_PYRFU; |
O58411, PORC_PYRHO; | Q5JIK2, PORC_THEKO; | P84820, PORC_THELN; |
O26801, VORA_METTH; | Q9UYZ1, VORA_PYRAB; | Q51801, VORA_PYRFU; |
O58413, VORA_PYRHO; | O26800, VORB_METTH; | P80908, VORB_METTM; |
Q9UYZ2, VORB_PYRAB; | Q51802, VORB_PYRFU; | O58414, VORB_PYRHO; |
O26799, VORC_METTH; | P80909, VORC_METTM; | Q9UYZ0, VORD_PYRAB; |
Q51800, VORD_PYRFU; | O58412, VORD_PYRHO; |
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