| Accepted Name |
|---|
| 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin).
|
| Alternative Name(s) |
|---|
| 2-ketoisovalerate ferredoxin reductase. |
| 2-oxoisovalerate ferredoxin reductase. |
| 3-methyl-2-oxobutanoate synthase (ferredoxin). |
| Branched-chain ketoacid ferredoxin reductase. |
| Branched-chain oxo acid ferredoxin reductase. |
| Keto-valine-ferredoxin oxidoreductase. |
| Ketoisovalerate ferredoxin reductase. |
| Ketoisovalerate oxidoreductase. |
| VOR. |
| Reaction catalysed |
|---|
| 3-methyl-2-oxobutanoate + CoA + 2 oxidized ferredoxin <=> S-(2-methylpropanoyl)-CoA + CO(2) + 2 reduced ferredoxin + H(+) |
| Cofactor(s) |
|---|
| Iron-sulfur; Tungstopterin.
|
| Comment(s) |
|---|
- The enzyme is CoA-dependent and contains thiamine diphosphate and
iron-sulfur clusters.
- Preferentially utilizes 2-oxo-acid derivatives of branched chain
amino acids, e.g. 3-methyl-2-oxopentanoate, 4-methyl-2-oxo-
pentanoate, and 2-oxobutanoate.
- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of
enzymes that reversibly catalyze the oxidative decarboxylation of
different 2-oxoacids to form their CoA derivatives, and are
differentiated based on their substrate specificity.
- For examples of other members of this family, see EC 1.2.7.1 and
EC 1.2.7.3.
|
| Cross-references |
|---|
| BRENDA | 1.2.7.7 |
| EC2PDB | 1.2.7.7 |
| ExplorEnz | 1.2.7.7 |
| PRIAM enzyme-specific profiles | 1.2.7.7 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.7.7 |
| IUBMB Enzyme Nomenclature | 1.2.7.7 |
| IntEnz | 1.2.7.7 |
| MEDLINE | Find literature relating to 1.2.7.7 |
| MetaCyc | 1.2.7.7 |
| Rhea expert-curated reactions | 1.2.7.7 |
| UniProtKB/Swiss-Prot |
| Q9UYY9, PORC_PYRAB; | P84819, PORC_PYREN; | Q51799, PORC_PYRFU; |
| O58411, PORC_PYRHO; | Q5JIK2, PORC_THEKO; | P84820, PORC_THELN; |
| O26801, VORA_METTH; | Q9UYZ1, VORA_PYRAB; | Q51801, VORA_PYRFU; |
| O58413, VORA_PYRHO; | O26800, VORB_METTH; | P80908, VORB_METTM; |
| Q9UYZ2, VORB_PYRAB; | Q51802, VORB_PYRFU; | O58414, VORB_PYRHO; |
| O26799, VORC_METTH; | P80909, VORC_METTM; | Q9UYZ0, VORD_PYRAB; |
| Q51800, VORD_PYRFU; | O58412, VORD_PYRHO; |
|