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ENZYME

ENZYME entry: EC 1.2.7.1

PURL: https://purl.expasy.org/enzyme/EC/1.2.7.1
Accepted Name
pyruvate synthase
Alternative Name(s)
2-oxobutyrate-ferredoxin oxidoreductase
2-oxobutyrate synthase
alpha-ketobutyrate-ferredoxin oxidoreductase
alpha-ketobutyrate synthase
pyruvate oxidoreductase
pyruvate synthetase
pyruvic-ferredoxin oxidoreductase
Reaction catalysed
2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate + CoA = 2 reduced [2Fe-2S]-[ferredoxin] + acetyl-CoA + CO2 + H(+)
Comment(s)
  • Contains thiamine diphosphate and [4Fe-4S] clusters.
  • The enzyme, common in bacteria, archaea, and some algae, catalyzes the reversible decarboxylation of pyruvate with the formation of acetyl-CoA.
  • Enzymes from different organisms catalyze the reaction in different directions depending on their metabolic needs.
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • In some organisms ferredoxin may be replaced by the flavin mononucleotide (FMN)-containing flavodoxin under conditions of low iron and high oxygen (cf. EC 1.2.8.1).
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
Cross-references
Rhea expert-curated reactions1.2.7.1
ExplorEnz1.2.7.1
IUBMB Enzyme Nomenclature1.2.7.1
UniProtKB/Swiss-Prot
P94692, PFOR_DESAFQ2RMD6, PFOR_MOOTAP80521, PORA_METBF
Q57715, PORA_METJAP56810, PORA_METTHP80900, PORA_METTM
Q9UYZ4, PORA_PYRABQ51804, PORA_PYRFUO73986, PORA_PYRHO
O05651, PORA_THEMAP80522, PORB_METBFQ57714, PORB_METJA
O27771, PORB_METTHP80901, PORB_METTMQ9UYZ5, PORB_PYRAB
Q51805, PORB_PYRFUO58417, PORB_PYRHOQ56317, PORB_THEMA
P80523, PORC_METBFQ57717, PORC_METJAO27772, PORC_METTH
P80902, PORC_METTMQ9UYY9, PORC_PYRABP84819, PORC_PYREN
Q51799, PORC_PYRFUO58411, PORC_PYRHOQ5JIK2, PORC_THEKO
P84820, PORC_THELNO05650, PORC_THEMA
BRENDA1.2.7.1
MetaCyc1.2.7.1
KEGG Ligand Database for Enzyme Nomenclature1.2.7.1
EC2PDB1.2.7.1
MEDLINEFind literature relating to 1.2.7.1

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