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ENZYME

ENZYME entry: EC 1.2.7.1

Accepted Name
pyruvate synthase
Alternative Name(s)
2-oxobutyrate-ferredoxin oxidoreductase
2-oxobutyrate synthase
alpha-ketobutyrate-ferredoxin oxidoreductase
alpha-ketobutyrate synthase
pyruvate oxidoreductase
pyruvate synthetase
pyruvic-ferredoxin oxidoreductase
Reaction catalysed
CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate.
  • This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
Cross-references
BRENDA1.2.7.1
EC2PDB1.2.7.1
ExplorEnz1.2.7.1
PRIAM enzyme-specific profiles1.2.7.1
KEGG Ligand Database for Enzyme Nomenclature1.2.7.1
IUBMB Enzyme Nomenclature1.2.7.1
IntEnz1.2.7.1
MEDLINEFind literature relating to 1.2.7.1
MetaCyc1.2.7.1
Rhea expert-curated reactions1.2.7.1
UniProtKB/Swiss-Prot
P94692, PFOR_DESAFQ2RMD6, PFOR_MOOTAP80521, PORA_METBF
Q57715, PORA_METJAP56810, PORA_METTHP80900, PORA_METTM
Q9UYZ4, PORA_PYRABQ51804, PORA_PYRFUO73986, PORA_PYRHO
O05651, PORA_THEMAP80522, PORB_METBFQ57714, PORB_METJA
O27771, PORB_METTHP80901, PORB_METTMQ9UYZ5, PORB_PYRAB
Q51805, PORB_PYRFUO58417, PORB_PYRHOQ56317, PORB_THEMA
P80523, PORC_METBFQ57717, PORC_METJAO27772, PORC_METTH
P80902, PORC_METTMQ9UYY9, PORC_PYRABP84819, PORC_PYREN
Q51799, PORC_PYRFUO58411, PORC_PYRHOQ5JIK2, PORC_THEKO
P84820, PORC_THELNO05650, PORC_THEMA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.7.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.-.-
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