ENZYME entry: EC 1.2.7.8
| Accepted Name |
|---|
| Indolepyruvate ferredoxin oxidoreductase.
|
| Alternative Name(s) |
|---|
| 3-(indol-3-yl)pyruvate synthase (ferredoxin). |
| IOR. |
| Reaction catalysed |
|---|
| (Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin <=> S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced ferredoxin + H(+) |
| Cofactor(s) |
|---|
| Iron-sulfur; Thiamine diphosphate.
|
| Comment(s) |
|---|
- Preferentially utilizes the transaminated forms of aromatic amino
acids and can use phenylpyruvate and 4-hydroxyphenylpyruvate as
substrates.
- This enzyme, which is found in archaea, is a member of the 2-oxoacid
oxidoreductases, a family of enzymes that oxidatively decarboxylate
different 2-oxoacids to form their CoA derivatives, and are
differentiated based on their substrate specificity.
- For examples of other members of this family, see EC 1.2.7.3 and
EC 1.2.7.7.
|
| Cross-references |
|---|
| BRENDA | 1.2.7.8 |
| EC2PDB | 1.2.7.8 |
| ExplorEnz | 1.2.7.8 |
| PRIAM enzyme-specific profiles | 1.2.7.8 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.2.7.8 |
| IUBMB Enzyme Nomenclature | 1.2.7.8 |
| IntEnz | 1.2.7.8 |
| MEDLINE | Find literature relating to 1.2.7.8 |
| MetaCyc | 1.2.7.8 |
| UniProtKB/Swiss-Prot |
| O28783, IORA_ARCFU; | O27880, IORA_METTH; | P80910, IORA_METTM; |
| Q9UZ57, IORA_PYRAB; | O58495, IORA_PYRHO; | O07835, IORA_THEKO; |
| O28249, IORB_ARCFU; | O27881, IORB_METTH; | P80911, IORB_METTM; |
| Q9UZ56, IORB_PYRAB; | O58496, IORB_PYRHO; | O07836, IORB_THEKO; |
|
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