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ENZYME entry: EC 1.2.7.8

Accepted Name
Indolepyruvate ferredoxin oxidoreductase.
Alternative Name(s)
3-(indol-3-yl)pyruvate synthase (ferredoxin).
IOR.
Reaction catalysed
(Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin <=> S-2-(indol-3-yl)acetyl-CoA + CO(2) + 2 reduced ferredoxin + H(+)
Cofactor(s)
Iron-sulfur; Thiamine diphosphate.
Comment(s)
  • Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and 4-hydroxyphenylpyruvate as substrates.
  • This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
  • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
Cross-references
BRENDA1.2.7.8
EC2PDB1.2.7.8
ExplorEnz1.2.7.8
PRIAM enzyme-specific profiles1.2.7.8
KEGG Ligand Database for Enzyme Nomenclature1.2.7.8
IUBMB Enzyme Nomenclature1.2.7.8
IntEnz1.2.7.8
MEDLINEFind literature relating to 1.2.7.8
MetaCyc1.2.7.8
Rhea expert-curated reactions1.2.7.8
UniProtKB/Swiss-Prot
O28783, IORA_ARCFU;  O27880, IORA_METTH;  P80910, IORA_METTM;  
Q9UZ57, IORA_PYRAB;  O58495, IORA_PYRHO;  O07835, IORA_THEKO;  
O28249, IORB_ARCFU;  O27881, IORB_METTH;  P80911, IORB_METTM;  
Q9UZ56, IORB_PYRAB;  O58496, IORB_PYRHO;  O07836, IORB_THEKO;  

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