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ENZYME

ENZYME entry: EC 1.21.4.2

Accepted Name
glycine reductase
Reaction catalysed
[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate
Comment(s)
  • The reaction is observed only in the direction of glycine reduction.
  • The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C.
  • Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release.
  • Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate.
  • Only subunit B distinguishes this enzyme from EC 1.21.4.3 and EC 1.21.4.4.
Cross-references
BRENDA1.21.4.2
EC2PDB1.21.4.2
ExplorEnz1.21.4.2
PRIAM enzyme-specific profiles1.21.4.2
KEGG Ligand Database for Enzyme Nomenclature1.21.4.2
IUBMB Enzyme Nomenclature1.21.4.2
IntEnz1.21.4.2
MEDLINEFind literature relating to 1.21.4.2
MetaCyc1.21.4.2
Rhea expert-curated reactions1.21.4.2
UniProtKB/Swiss-Prot
P50972, GRDA1_PEPACQ6LH20, GRDA1_PHOPRO32518, GRDA2_PEPAC
Q6LH19, GRDA2_PHOPRP26971, GRDA_ACESDA6TU46, GRDA_ALKMQ
Q3A9J5, GRDA_CARHZA7FTE0, GRDA_CLOB1A7GCV1, GRDA_CLOBL
P26970, GRDA_GOTPUP52216, GRDA_PEPLIQ67KE6, GRDA_SYMTH
Q73PQ2, GRDA_TREDEQ3A9J4, GRDB_CARHZP55793, GRDB_GOTPU
Q9R4G8, GRDB_PEPACP52217, GRDB_PEPLIQ67KE7, GRDB_SYMTH
P54935, GRDC_PEPACQ47878, GRDD_PEPACQ9EV94, GRDE_ACESD
Q9R4G7, GRDE_PEPAC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
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