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ENZYME entry: EC 1.21.4.2
Accepted Name |
glycine reductase.
|
Reaction catalysed |
[thioredoxin]-disulfide + acetyl phosphate + H2O + NH4(+) <=> [thioredoxin]-dithiol + glycine + H(+) + phosphate |
Comment(s) |
- The reaction is observed only in the direction of glycine reduction.
- The enzyme from Eubacterium acidaminophilum consists of subunits A,
B and C.
- Subunit B contains selenocysteine and a pyruvoyl group, and is
responsible for glycine binding and ammonia release.
- Subunit A, which also contains selenocysteine, is reduced by
thioredoxin, and is needed to convert the carboxymethyl group into a
ketene equivalent, in turn used by subunit C to produce acetyl
phosphate.
- Only subunit B distinguishes this enzyme from EC 1.21.4.3 and
EC 1.21.4.4.
|
Cross-references |
BRENDA | 1.21.4.2 |
EC2PDB | 1.21.4.2 |
ExplorEnz | 1.21.4.2 |
PRIAM enzyme-specific profiles | 1.21.4.2 |
KEGG Ligand Database for Enzyme Nomenclature | 1.21.4.2 |
IUBMB Enzyme Nomenclature | 1.21.4.2 |
IntEnz | 1.21.4.2 |
MEDLINE | Find literature relating to 1.21.4.2 |
MetaCyc | 1.21.4.2 |
Rhea expert-curated reactions | 1.21.4.2 |
UniProtKB/Swiss-Prot |
P50972, GRDA1_PEPAC; | Q6LH20, GRDA1_PHOPR; | O32518, GRDA2_PEPAC; |
Q6LH19, GRDA2_PHOPR; | P26971, GRDA_ACESD; | A6TU46, GRDA_ALKMQ; |
Q3A9J5, GRDA_CARHZ; | A7FTE0, GRDA_CLOB1; | A7GCV1, GRDA_CLOBL; |
P26970, GRDA_GOTPU; | P52216, GRDA_PEPLI; | Q67KE6, GRDA_SYMTH; |
Q73PQ2, GRDA_TREDE; | Q3A9J4, GRDB_CARHZ; | P55793, GRDB_GOTPU; |
Q9R4G8, GRDB_PEPAC; | P52217, GRDB_PEPLI; | Q67KE7, GRDB_SYMTH; |
P54935, GRDC_PEPAC; | Q47878, GRDD_PEPAC; | Q9EV94, GRDE_ACESD; |
Q9R4G7, GRDE_PEPAC; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-