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ENZYME entry: EC 1.21.4.3

Accepted Name
sarcosine reductase.
Reaction catalysed
[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine
Comment(s)
  • The reaction is observed only in the direction of sarcosine reduction.
  • The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C.
  • Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release.
  • Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate.
  • Only subunit B distinguishes this enzyme from EC 1.21.4.2 and EC 1.21.4.4.
Cross-references
BRENDA1.21.4.3
EC2PDB1.21.4.3
ExplorEnz1.21.4.3
PRIAM enzyme-specific profiles1.21.4.3
KEGG Ligand Database for Enzyme Nomenclature1.21.4.3
IUBMB Enzyme Nomenclature1.21.4.3
IntEnz1.21.4.3
MEDLINEFind literature relating to 1.21.4.3
MetaCyc1.21.4.3
Rhea expert-curated reactions1.21.4.3
UniProtKB/Swiss-Prot
P50972, GRDA1_PEPAC;  Q6LH20, GRDA1_PHOPR;  O32518, GRDA2_PEPAC;  
Q6LH19, GRDA2_PHOPR;  P26971, GRDA_ACESD;  A6TU46, GRDA_ALKMQ;  
Q3A9J5, GRDA_CARHZ;  A7FTE0, GRDA_CLOB1;  A7GCV1, GRDA_CLOBL;  
P26970, GRDA_GOTPU;  P52216, GRDA_PEPLI;  Q67KE6, GRDA_SYMTH;  
Q73PQ2, GRDA_TREDE;  P54935, GRDC_PEPAC;  Q47878, GRDD_PEPAC;  
O86186, GRDF_PEPAC;  O86185, GRDG_PEPAC;  

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