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ENZYME entry: EC 1.21.4.3
Accepted Name |
sarcosine reductase.
|
Reaction catalysed |
[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine <=> [thioredoxin]-dithiol + H(+) + phosphate + sarcosine |
Comment(s) |
- The reaction is observed only in the direction of sarcosine
reduction.
- The enzyme from Eubacterium acidaminophilum consists of subunits A,
B and C.
- Subunit B contains selenocysteine and a pyruvoyl group, and is
responsible for sarcosine binding and methylamine release.
- Subunit A, which also contains selenocysteine, is reduced by
thioredoxin, and is needed to convert the carboxymethyl group into a
ketene equivalent, in turn used by subunit C to produce acetyl
phosphate.
- Only subunit B distinguishes this enzyme from EC 1.21.4.2 and
EC 1.21.4.4.
|
Cross-references |
BRENDA | 1.21.4.3 |
EC2PDB | 1.21.4.3 |
ExplorEnz | 1.21.4.3 |
PRIAM enzyme-specific profiles | 1.21.4.3 |
KEGG Ligand Database for Enzyme Nomenclature | 1.21.4.3 |
IUBMB Enzyme Nomenclature | 1.21.4.3 |
IntEnz | 1.21.4.3 |
MEDLINE | Find literature relating to 1.21.4.3 |
MetaCyc | 1.21.4.3 |
Rhea expert-curated reactions | 1.21.4.3 |
UniProtKB/Swiss-Prot |
P50972, GRDA1_PEPAC; | Q6LH20, GRDA1_PHOPR; | O32518, GRDA2_PEPAC; |
Q6LH19, GRDA2_PHOPR; | P26971, GRDA_ACESD; | A6TU46, GRDA_ALKMQ; |
Q3A9J5, GRDA_CARHZ; | A7FTE0, GRDA_CLOB1; | A7GCV1, GRDA_CLOBL; |
P26970, GRDA_GOTPU; | P52216, GRDA_PEPLI; | Q67KE6, GRDA_SYMTH; |
Q73PQ2, GRDA_TREDE; | P54935, GRDC_PEPAC; | Q47878, GRDD_PEPAC; |
O86186, GRDF_PEPAC; | O86185, GRDG_PEPAC; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
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