Expasy logo

ENZYME

ENZYME entry: EC 1.21.4.3

Accepted Name
sarcosine reductase
Reaction catalysed
[thioredoxin]-disulfide + acetyl phosphate + H2O + methylamine = [thioredoxin]-dithiol + H(+) + phosphate + sarcosine
Comment(s)
  • The reaction is observed only in the direction of sarcosine reduction.
  • The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C.
  • Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for sarcosine binding and methylamine release.
  • Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate.
  • Only subunit B distinguishes this enzyme from EC 1.21.4.2 and EC 1.21.4.4.
Cross-references
BRENDA1.21.4.3
EC2PDB1.21.4.3
ExplorEnz1.21.4.3
PRIAM enzyme-specific profiles1.21.4.3
KEGG Ligand Database for Enzyme Nomenclature1.21.4.3
IUBMB Enzyme Nomenclature1.21.4.3
IntEnz1.21.4.3
MEDLINEFind literature relating to 1.21.4.3
MetaCyc1.21.4.3
Rhea expert-curated reactions1.21.4.3
UniProtKB/Swiss-Prot
P50972, GRDA1_PEPACQ6LH20, GRDA1_PHOPRO32518, GRDA2_PEPAC
Q6LH19, GRDA2_PHOPRP26971, GRDA_ACESDA6TU46, GRDA_ALKMQ
Q3A9J5, GRDA_CARHZA7FTE0, GRDA_CLOB1A7GCV1, GRDA_CLOBL
P26970, GRDA_GOTPUP52216, GRDA_PEPLIQ67KE6, GRDA_SYMTH
Q73PQ2, GRDA_TREDEP54935, GRDC_PEPACQ47878, GRDD_PEPAC
O86186, GRDF_PEPACO86185, GRDG_PEPAC

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-