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ENZYME

ENZYME entry: EC 1.21.4.4

PURL: https://purl.expasy.org/enzyme/EC/1.21.4.4
Accepted Name
betaine reductase
Reaction catalysed
acetyl phosphate + trimethylamine + [thioredoxin]-disulfide + H2O = glycine betaine + [thioredoxin]-dithiol + phosphate + H(+)
Comment(s)
  • The reaction is observed only in the direction of betaine reduction.
  • The enzyme from Eubacterium acidaminophilum consists of subunits A, B and C.
  • Subunit B contains selenocysteine and a pyruvoyl group, and is responsible for glycine binding and ammonia release.
  • Subunit A, which also contains selenocysteine, is reduced by thioredoxin, and is needed to convert the carboxymethyl group into a ketene equivalent, in turn used by subunit C to produce acetyl phosphate.
  • Only subunit B distinguishes this enzyme from EC 1.21.4.2 and EC 1.21.4.3.
Cross-references
BRENDA1.21.4.4
EC2PDB1.21.4.4
ExplorEnz1.21.4.4
KEGG Ligand Database for Enzyme Nomenclature1.21.4.4
IUBMB Enzyme Nomenclature1.21.4.4
MEDLINEFind literature relating to 1.21.4.4
MetaCyc1.21.4.4
Rhea expert-curated reactions1.21.4.4
UniProtKB/Swiss-Prot
P50972, GRDA1_PEPACQ6LH20, GRDA1_PHOPRO32518, GRDA2_PEPAC
Q6LH19, GRDA2_PHOPRP26971, GRDA_ACESDA6TU46, GRDA_ALKMQ
Q3A9J5, GRDA_CARHZA7FTE0, GRDA_CLOB1A7GCV1, GRDA_CLOBL
P26970, GRDA_GOTPUP52216, GRDA_PEPLIQ67KE6, GRDA_SYMTH
Q73PQ2, GRDA_TREDEP54935, GRDC_PEPACQ47878, GRDD_PEPAC
O69407, GRDH_PEPACO69406, GRDI_PEPAC

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.21.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-