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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Dichlorochromopyrrolate synthase.
Reaction catalysed
2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H(2)O(2) <=> dichlorochromopyrrolate + NH(3) + 2 H(2)O
Fe cation; Heme b.
  • This enzyme catalyzes a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • The enzyme is a dimeric heme-protein oxidase that catalyzes the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin.
  • In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC as the electron acceptor.
  • However, the enzyme is also able to catalyze the reaction using molecular oxygen.
  • Formerly EC and EC
PRIAM enzyme-specific profiles1.21.98.2
KEGG Ligand Database for Enzyme Nomenclature1.21.98.2
IUBMB Enzyme Nomenclature1.21.98.2
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