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ENZYME

ENZYME entry: EC 1.21.98.2

PURL: https://purl.expasy.org/enzyme/EC/1.21.98.2
Accepted Name
dichlorochromopyrrolate synthase
Reaction catalysed
2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H2O2 = dichlorochromopyrrolate + NH4(+) + 2 H2O + H(+)
Comment(s)
  • This enzyme catalyzes a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • The enzyme is a dimeric heme-protein oxidase that catalyzes the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin.
  • In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC 1.4.3.23) as the electron acceptor.
  • However, the enzyme is also able to catalyze the reaction using molecular oxygen.
  • Formerly EC 1.21.3.9 and EC 4.3.1.26.
Cross-references
BRENDA1.21.98.2
EC2PDB1.21.98.2
ExplorEnz1.21.98.2
KEGG Ligand Database for Enzyme Nomenclature1.21.98.2
IUBMB Enzyme Nomenclature1.21.98.2
MEDLINEFind literature relating to 1.21.98.2
MetaCyc1.21.98.2
Rhea expert-curated reactions1.21.98.2
UniProtKB/Swiss-Prot
Q8KHV6, REBD_LENAE

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