A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 1.21.98.2
| Accepted Name |
|---|
| Dichlorochromopyrrolate synthase.
|
| Reaction catalysed |
|---|
| 2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H(2)O(2) <=> dichlorochromopyrrolate + NH(3) + 2 H(2)O |
| Cofactor(s) |
|---|
| Fe cation; Heme b.
|
| Comment(s) |
|---|
- This enzyme catalyzes a step in the biosynthesis of rebeccamycin,
an indolocarbazole alkaloid produced by the bacterium Lechevalieria
aerocolonigenes.
- The enzyme is a dimeric heme-protein oxidase that catalyzes the
oxidative dimerization of two L-tryptophan-derived molecules to form
dichlorochromopyrrolic acid, the precursor for the fused six-ring
indolocarbazole scaffold of rebeccamycin.
- In vivo the enzyme uses hydrogen peroxide, formed by the enzyme
upstream in the biosynthetic pathway (EC 1.4.3.23) as the electron
acceptor.
- However, the enzyme is also able to catalyze the reaction using
molecular oxygen.
- Formerly EC 1.21.3.9 and EC 4.3.1.26.
|
| Cross-references |
|---|
| BRENDA | 1.21.98.2 |
| EC2PDB | 1.21.98.2 |
| ExplorEnz | 1.21.98.2 |
| PRIAM enzyme-specific profiles | 1.21.98.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.21.98.2 |
| IUBMB Enzyme Nomenclature | 1.21.98.2 |
| IntEnz | 1.21.98.2 |
| MEDLINE | Find literature relating to 1.21.98.2 |
| MetaCyc | 1.21.98.2 |
| UniProtKB/Swiss-Prot |
|
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