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ENZYME entry: EC 1.21.98.2

Accepted Name
Dichlorochromopyrrolate synthase.
Reaction catalysed
2 3-(7-chloroindol-3-yl)-2-iminopropanoate + H(2)O(2) <=> dichlorochromopyrrolate + NH(3) + 2 H(2)O
Cofactor(s)
Fe cation; Heme b.
Comment(s)
  • This enzyme catalyzes a step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the bacterium Lechevalieria aerocolonigenes.
  • The enzyme is a dimeric heme-protein oxidase that catalyzes the oxidative dimerization of two L-tryptophan-derived molecules to form dichlorochromopyrrolic acid, the precursor for the fused six-ring indolocarbazole scaffold of rebeccamycin.
  • In vivo the enzyme uses hydrogen peroxide, formed by the enzyme upstream in the biosynthetic pathway (EC 1.4.3.23) as the electron acceptor.
  • However, the enzyme is also able to catalyze the reaction using molecular oxygen.
  • Formerly EC 1.21.3.9 and EC 4.3.1.26.
Cross-references
BRENDA1.21.98.2
EC2PDB1.21.98.2
ExplorEnz1.21.98.2
PRIAM enzyme-specific profiles1.21.98.2
KEGG Ligand Database for Enzyme Nomenclature1.21.98.2
IUBMB Enzyme Nomenclature1.21.98.2
IntEnz1.21.98.2
MEDLINEFind literature relating to 1.21.98.2
MetaCyc1.21.98.2
Rhea expert-curated reactions1.21.98.2
UniProtKB/Swiss-Prot
Q8KHV6, REBD_LENAE

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