ENZYME entry: EC 1.3.1.115
Accepted Name |
3-oxocholoyl-CoA 4-desaturase.
|
Alternative Name(s) |
3-oxo-choloyl-CoA dehydrogenase. |
Reaction catalysed |
- 7-alpha,12-alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7-alpha,12-alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH
- 7-alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH
|
Cofactor(s) |
Flavoprotein.
|
Comment(s) |
- The enzyme, characterized from the bacterium Clostridium scindens,
participates in the bile acid 7-alpha-dehydroxylation pathway.
- The enzyme catalyzes the stereo-specific oxidation of its substrates
and has no activity with the 7-beta anomers.
- Cf. EC 1.3.1.116.
|
Cross-references |
BRENDA | 1.3.1.115 |
EC2PDB | 1.3.1.115 |
ExplorEnz | 1.3.1.115 |
PRIAM enzyme-specific profiles | 1.3.1.115 |
KEGG Ligand Database for Enzyme Nomenclature | 1.3.1.115 |
IUBMB Enzyme Nomenclature | 1.3.1.115 |
IntEnz | 1.3.1.115 |
MEDLINE | Find literature relating to 1.3.1.115 |
MetaCyc | 1.3.1.115 |
Rhea expert-curated reactions | 1.3.1.115 |
UniProtKB/Swiss-Prot |
|
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