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ENZYME entry: EC 1.3.1.115

Accepted Name
3-oxocholoyl-CoA 4-desaturase.
Alternative Name(s)
3-oxo-choloyl-CoA dehydrogenase.
Reaction catalysed
  • 7-alpha,12-alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7-alpha,12-alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH
  • 7-alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD(+) <=> 7-alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH
Cofactor(s)
Flavoprotein.
Comment(s)
  • The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7-alpha-dehydroxylation pathway.
  • The enzyme catalyzes the stereo-specific oxidation of its substrates and has no activity with the 7-beta anomers.
  • Cf. EC 1.3.1.116.
Cross-references
BRENDA1.3.1.115
EC2PDB1.3.1.115
ExplorEnz1.3.1.115
PRIAM enzyme-specific profiles1.3.1.115
KEGG Ligand Database for Enzyme Nomenclature1.3.1.115
IUBMB Enzyme Nomenclature1.3.1.115
IntEnz1.3.1.115
MEDLINEFind literature relating to 1.3.1.115
MetaCyc1.3.1.115
Rhea expert-curated reactions1.3.1.115
UniProtKB/Swiss-Prot
P19410, BAICD_CLOSV

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