ENZYME entry: EC 1.3.1.14

PURL: https://purl.expasy.org/enzyme/EC/1.3.1.14

Accepted Name

dihydroorotate dehydrogenase (NAD(+))

Alternative Name(s)

DHOD

DHODase

DHOdehase

dihydroorotate oxidase

orotate reductase (NADH)

orotate reductase (NADH2)

Reaction catalysed

(S)-dihydroorotate + NAD(+) = orotate + NADH + H(+)

Comment(s)

The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.

Cross-references

BRENDA

1.3.1.14

EC2PDB

1.3.1.14

ExplorEnz

1.3.1.14

KEGG Ligand Database for Enzyme Nomenclature

1.3.1.14

IUBMB Enzyme Nomenclature

1.3.1.14

MEDLINE

Find literature relating to 1.3.1.14

MetaCyc

1.3.1.14

Rhea expert-curated reactions

1.3.1.14

UniProtKB/Swiss-Prot

A6TVS0, PYRDB_ALKMQ	A8MIU4, PYRDB_ALKOO	B7GFA1, PYRDB_ANOFW
O29513, PYRDB_ARCFU	B6YRL9, PYRDB_AZOPC	C3P654, PYRDB_BACAA
C3L742, PYRDB_BACAC	A0RHQ6, PYRDB_BACAH	Q81WF4, PYRDB_BACAN
B7JJX1, PYRDB_BACC0	Q732I5, PYRDB_BACC1	B7IUP4, PYRDB_BACC2
C1EPP8, PYRDB_BACC3	B7H6M0, PYRDB_BACC4	B7HLL8, PYRDB_BACC7
P46539, PYRDB_BACCL	A7GRK9, PYRDB_BACCN	B9IVW1, PYRDB_BACCQ
Q819S5, PYRDB_BACCR	Q636E2, PYRDB_BACCZ	Q5LCI2, PYRDB_BACFN
Q64TN0, PYRDB_BACFR	Q6HET0, PYRDB_BACHK	A9VTC4, PYRDB_BACMK
A8FD19, PYRDB_BACP2	P25996, PYRDB_BACSU	Q8A9C3, PYRDB_BACTN
A7Z4H4, PYRDB_BACVZ	C0QYH6, PYRDB_BRAHW	B9MS26, PYRDB_CALBD
Q8R9R7, PYRDB_CALS4	A4XKT6, PYRDB_CALS8	Q3AC05, PYRDB_CARHZ
B5EFU4, PYRDB_CITBB	Q18CS6, PYRDB_CLOD6	Q6A912, PYRDB_CUTAK
B1I4M6, PYRDB_DESAP	A4J560, PYRDB_DESRM	B1GYY3, PYRDB_ENDTX
P0DH74, PYRDB_ENTFA	F2MMN9, PYRDB_ENTFO	B1YIR7, PYRDB_EXIS2
Q8RG85, PYRDB_FUSNN	B9M211, PYRDB_GEODF	Q5L0U1, PYRDB_GEOKA
Q39UK4, PYRDB_GEOMG	Q74CB9, PYRDB_GEOSL	C6E6N2, PYRDB_GEOSM
C5D8Q2, PYRDB_GEOSW	A4IM35, PYRDB_GEOTN	A5G3H0, PYRDB_GEOUR
Q9K9W1, PYRDB_HALH5	B0TGQ8, PYRDB_HELMI	Q9CFW8, PYRDB_LACLA
P54322, PYRDB_LACLM	A9KKR5, PYRDB_LACP7	Q38X22, PYRDB_LATSS
Q92AH5, PYRDB_LISIN	C1KWD2, PYRDB_LISMC	Q71YI3, PYRDB_LISMF
B8DDR9, PYRDB_LISMH	Q8Y667, PYRDB_LISMO	A0AJT8, PYRDB_LISW6
Q8EUY2, PYRDB_MALP2	C6BW12, PYRDB_MARSD	Q8TT55, PYRDB_METAC
Q0W8E1, PYRDB_METAR	Q58070, PYRDB_METJA	Q8TXU6, PYRDB_METKA
Q8PW56, PYRDB_METMA	O27281, PYRDB_METTH	B2A2U4, PYRDB_NATTJ
Q8CWG1, PYRDB_OCEIH	A6LB11, PYRDB_PARD8	A1ASB3, PYRDB_PELPD
A9BJH4, PYRDB_PETMO	A6L5H1, PYRDB_PHOV8	Q7MVJ6, PYRDB_PORGI
Q9V0Y6, PYRDB_PYRAB	Q8U0P6, PYRDB_PYRFU	O59185, PYRDB_PYRHO
Q9UX04, PYRDB_SACS2	Q5WFJ4, PYRDB_SHOC1	C4XPD6, PYRDB_SOLM1
B9DPN4, PYRDB_STACT	Q97R65, PYRDB_STRPN	Q8DQ37, PYRDB_STRR6
O08358, PYRDB_SULAC	Q0AXG6, PYRDB_SYNWW	Q9HL35, PYRDB_THEAC
Q5JHR7, PYRDB_THEKO	Q9WYG8, PYRDB_THEMA	A5IK84, PYRDB_THEP1
B0KA32, PYRDB_THEP3	B0K2E5, PYRDB_THEPX	Q979G6, PYRDB_THEVO
B5YJH1, PYRDB_THEYD	B3E4T4, PYRDB_TRIL1

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