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ENZYME entry: EC 1.3.1.14

Accepted Name
Dihydroorotate dehydrogenase (NAD(+)).
Alternative Name(s)
DHOD.
DHODase.
DHOdehase.
Dihydroorotate oxidase.
Orotate reductase (NADH(2)).
Orotate reductase (NADH).
Reaction catalysed
(S)-dihydroorotate + NAD(+) <=> orotate + NADH
Cofactor(s)
FAD; FMN; Iron-sulfur.
Comment(s)
  • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
Cross-references
BRENDA1.3.1.14
EC2PDB1.3.1.14
ExplorEnz1.3.1.14
PRIAM enzyme-specific profiles1.3.1.14
KEGG Ligand Database for Enzyme Nomenclature1.3.1.14
IUBMB Enzyme Nomenclature1.3.1.14
IntEnz1.3.1.14
MEDLINEFind literature relating to 1.3.1.14
MetaCyc1.3.1.14
Rhea expert-curated reactions1.3.1.14
UniProtKB/Swiss-Prot
Q5WFJ4, PYRDB_ALKCK;  Q9K9W1, PYRDB_ALKHC;  A6TVS0, PYRDB_ALKMQ;  
A8MIU4, PYRDB_ALKOO;  B7GFA1, PYRDB_ANOFW;  O29513, PYRDB_ARCFU;  
B6YRL9, PYRDB_AZOPC;  C3P654, PYRDB_BACAA;  C3L742, PYRDB_BACAC;  
A0RHQ6, PYRDB_BACAH;  Q81WF4, PYRDB_BACAN;  B7JJX1, PYRDB_BACC0;  
Q732I5, PYRDB_BACC1;  B7IUP4, PYRDB_BACC2;  C1EPP8, PYRDB_BACC3;  
B7H6M0, PYRDB_BACC4;  B7HLL8, PYRDB_BACC7;  P46539, PYRDB_BACCL;  
A7GRK9, PYRDB_BACCN;  B9IVW1, PYRDB_BACCQ;  Q819S5, PYRDB_BACCR;  
Q636E2, PYRDB_BACCZ;  Q5LCI2, PYRDB_BACFN;  Q64TN0, PYRDB_BACFR;  
Q6HET0, PYRDB_BACHK;  A9VTC4, PYRDB_BACMK;  A8FD19, PYRDB_BACP2;  
P25996, PYRDB_BACSU;  Q8A9C3, PYRDB_BACTN;  A7Z4H4, PYRDB_BACVZ;  
C0QYH6, PYRDB_BRAHW;  B9MS26, PYRDB_CALBD;  Q8R9R7, PYRDB_CALS4;  
A4XKT6, PYRDB_CALS8;  Q3AC05, PYRDB_CARHZ;  B5EFU4, PYRDB_CITBB;  
Q18CS6, PYRDB_CLOD6;  Q6A912, PYRDB_CUTAK;  B1I4M6, PYRDB_DESAP;  
A4J560, PYRDB_DESRM;  B1GYY3, PYRDB_ENDTX;  P0DH74, PYRDB_ENTFA;  
F2MMN9, PYRDB_ENTFO;  B1YIR7, PYRDB_EXIS2;  Q8RG85, PYRDB_FUSNN;  
B9M211, PYRDB_GEODF;  Q5L0U1, PYRDB_GEOKA;  Q39UK4, PYRDB_GEOMG;  
Q74CB9, PYRDB_GEOSL;  C6E6N2, PYRDB_GEOSM;  C5D8Q2, PYRDB_GEOSW;  
A4IM35, PYRDB_GEOTN;  A5G3H0, PYRDB_GEOUR;  B0TGQ8, PYRDB_HELMI;  
Q9CFW8, PYRDB_LACLA;  P54322, PYRDB_LACLM;  A9KKR5, PYRDB_LACP7;  
Q38X22, PYRDB_LATSS;  Q92AH5, PYRDB_LISIN;  C1KWD2, PYRDB_LISMC;  
Q71YI3, PYRDB_LISMF;  B8DDR9, PYRDB_LISMH;  Q8Y667, PYRDB_LISMO;  
A0AJT8, PYRDB_LISW6;  C6BW12, PYRDB_MARSD;  Q8TT55, PYRDB_METAC;  
Q0W8E1, PYRDB_METAR;  Q58070, PYRDB_METJA;  Q8TXU6, PYRDB_METKA;  
Q8PW56, PYRDB_METMA;  O27281, PYRDB_METTH;  Q8EUY2, PYRDB_MYCPE;  
B2A2U4, PYRDB_NATTJ;  Q8CWG1, PYRDB_OCEIH;  A6LB11, PYRDB_PARD8;  
A1ASB3, PYRDB_PELPD;  A9BJH4, PYRDB_PETMO;  A6L5H1, PYRDB_PHOV8;  
Q7MVJ6, PYRDB_PORGI;  Q9V0Y6, PYRDB_PYRAB;  Q8U0P6, PYRDB_PYRFU;  
O59185, PYRDB_PYRHO;  Q9UX04, PYRDB_SACS2;  C4XPD6, PYRDB_SOLM1;  
B9DPN4, PYRDB_STACT;  Q97R65, PYRDB_STRPN;  Q8DQ37, PYRDB_STRR6;  
O08358, PYRDB_SULAC;  Q0AXG6, PYRDB_SYNWW;  Q9HL35, PYRDB_THEAC;  
Q5JHR7, PYRDB_THEKO;  Q9WYG8, PYRDB_THEMA;  A5IK84, PYRDB_THEP1;  
B0KA32, PYRDB_THEP3;  B0K2E5, PYRDB_THEPX;  Q979G6, PYRDB_THEVO;  
B5YJH1, PYRDB_THEYD;  B3E4T4, PYRDB_TRIL1;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
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