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ENZYME

ENZYME entry: EC 1.3.1.14

Accepted Name
dihydroorotate dehydrogenase (NAD(+))
Alternative Name(s)
DHOD
DHODase
DHOdehase
dihydroorotate oxidase
orotate reductase (NADH)
orotate reductase (NADH2)
Reaction catalysed
(S)-dihydroorotate + NAD(+) <=> H(+) + NADH + orotate
Comment(s)
  • The enzyme consists of two subunits, an FMN binding catalytic subunit and a FAD and iron-sulfur binding electron transfer subunit.
  • The reaction, which takes place in the cytosol, is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • Other class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor.
Cross-references
BRENDA1.3.1.14
EC2PDB1.3.1.14
ExplorEnz1.3.1.14
PRIAM enzyme-specific profiles1.3.1.14
KEGG Ligand Database for Enzyme Nomenclature1.3.1.14
IUBMB Enzyme Nomenclature1.3.1.14
IntEnz1.3.1.14
MEDLINEFind literature relating to 1.3.1.14
MetaCyc1.3.1.14
Rhea expert-curated reactions1.3.1.14
UniProtKB/Swiss-Prot
Q5WFJ4, PYRDB_ALKCKA6TVS0, PYRDB_ALKMQA8MIU4, PYRDB_ALKOO
B7GFA1, PYRDB_ANOFWO29513, PYRDB_ARCFUB6YRL9, PYRDB_AZOPC
C3P654, PYRDB_BACAAC3L742, PYRDB_BACACA0RHQ6, PYRDB_BACAH
Q81WF4, PYRDB_BACANB7JJX1, PYRDB_BACC0Q732I5, PYRDB_BACC1
B7IUP4, PYRDB_BACC2C1EPP8, PYRDB_BACC3B7H6M0, PYRDB_BACC4
B7HLL8, PYRDB_BACC7P46539, PYRDB_BACCLA7GRK9, PYRDB_BACCN
B9IVW1, PYRDB_BACCQQ819S5, PYRDB_BACCRQ636E2, PYRDB_BACCZ
Q5LCI2, PYRDB_BACFNQ64TN0, PYRDB_BACFRQ6HET0, PYRDB_BACHK
A9VTC4, PYRDB_BACMKA8FD19, PYRDB_BACP2P25996, PYRDB_BACSU
Q8A9C3, PYRDB_BACTNA7Z4H4, PYRDB_BACVZC0QYH6, PYRDB_BRAHW
B9MS26, PYRDB_CALBDQ8R9R7, PYRDB_CALS4A4XKT6, PYRDB_CALS8
Q3AC05, PYRDB_CARHZB5EFU4, PYRDB_CITBBQ18CS6, PYRDB_CLOD6
Q6A912, PYRDB_CUTAKB1I4M6, PYRDB_DESAPA4J560, PYRDB_DESRM
B1GYY3, PYRDB_ENDTXP0DH74, PYRDB_ENTFAF2MMN9, PYRDB_ENTFO
B1YIR7, PYRDB_EXIS2Q8RG85, PYRDB_FUSNNB9M211, PYRDB_GEODF
Q5L0U1, PYRDB_GEOKAQ39UK4, PYRDB_GEOMGQ74CB9, PYRDB_GEOSL
C6E6N2, PYRDB_GEOSMC5D8Q2, PYRDB_GEOSWA4IM35, PYRDB_GEOTN
A5G3H0, PYRDB_GEOURQ9K9W1, PYRDB_HALH5B0TGQ8, PYRDB_HELMI
Q9CFW8, PYRDB_LACLAP54322, PYRDB_LACLMA9KKR5, PYRDB_LACP7
Q38X22, PYRDB_LATSSQ92AH5, PYRDB_LISINC1KWD2, PYRDB_LISMC
Q71YI3, PYRDB_LISMFB8DDR9, PYRDB_LISMHQ8Y667, PYRDB_LISMO
A0AJT8, PYRDB_LISW6Q8EUY2, PYRDB_MALP2C6BW12, PYRDB_MARSD
Q8TT55, PYRDB_METACQ0W8E1, PYRDB_METARQ58070, PYRDB_METJA
Q8TXU6, PYRDB_METKAQ8PW56, PYRDB_METMAO27281, PYRDB_METTH
B2A2U4, PYRDB_NATTJQ8CWG1, PYRDB_OCEIHA6LB11, PYRDB_PARD8
A1ASB3, PYRDB_PELPDA9BJH4, PYRDB_PETMOA6L5H1, PYRDB_PHOV8
Q7MVJ6, PYRDB_PORGIQ9V0Y6, PYRDB_PYRABQ8U0P6, PYRDB_PYRFU
O59185, PYRDB_PYRHOQ9UX04, PYRDB_SACS2C4XPD6, PYRDB_SOLM1
B9DPN4, PYRDB_STACTQ97R65, PYRDB_STRPNQ8DQ37, PYRDB_STRR6
O08358, PYRDB_SULACQ0AXG6, PYRDB_SYNWWQ9HL35, PYRDB_THEAC
Q5JHR7, PYRDB_THEKOQ9WYG8, PYRDB_THEMAA5IK84, PYRDB_THEP1
B0KA32, PYRDB_THEP3B0K2E5, PYRDB_THEPXQ979G6, PYRDB_THEVO
B5YJH1, PYRDB_THEYDB3E4T4, PYRDB_TRIL1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
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