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ENZYME

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ENZYME entry: EC 1.3.5.2

Accepted Name
dihydroorotate dehydrogenase (quinone)
Alternative Name(s)
DHOD
DHOdehase
DHODH
Reaction catalysed
(S)-dihydroorotate + a quinone = a quinol + orotate
Comment(s)
  • This Class 2 dihydroorotate dehydrogenase enzyme contains FMN.
  • The enzyme is found in eukaryotes in the mitochondrial membrane, in cyanobacteria, and in some Gram-negative and Gram-positive bacteria associated with the cytoplasmic membrane.
  • The reaction is the only redox reaction in the de-novo biosynthesis of pyrimidine nucleotides.
  • The best quinone electron acceptors for the enzyme from bovine liver are ubiquinone-6 and ubiquinone-7, although simple quinones, such as benzoquinone, can also act as acceptor at lower rates.
  • Methyl-, ethyl-, tert-butyl and benzyl-(S)-dihydroorotates are also substrates, but methyl esters of (S)-1-methyl and (S)-3-methyl and (S)-1,3-dimethyldihydroorotates are not.
  • Class 1 dihydroorotate dehydrogenases use either fumarate (EC 1.3.98.1), NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor.
  • Formerly EC 1.3.99.11.
Cross-references
BRENDA1.3.5.2
EC2PDB1.3.5.2
ExplorEnz1.3.5.2
PRIAM enzyme-specific profiles1.3.5.2
KEGG Ligand Database for Enzyme Nomenclature1.3.5.2
IUBMB Enzyme Nomenclature1.3.5.2
IntEnz1.3.5.2
MEDLINEFind literature relating to 1.3.5.2
MetaCyc1.3.5.2
Rhea expert-curated reactions1.3.5.2
UniProtKB/Swiss-Prot
Q6CTX8, PYRD2_KLULAQ6SZS6, PYRD2_KLUMAB0CA74, PYRD_ACAM1
Q6FCL9, PYRD_ACIADB7GZW7, PYRD_ACIB3B7I2L5, PYRD_ACIB5
B2HUT6, PYRD_ACIBCB0VKB8, PYRD_ACIBSA3M6Y2, PYRD_ACIBT
B0V824, PYRD_ACIBYB9MIU2, PYRD_ACIETB7J5Q1, PYRD_ACIF2
B5EL46, PYRD_ACIF5A1W7S6, PYRD_ACISJA3N0D6, PYRD_ACTP2
B3H1B5, PYRD_ACTP7B0BP55, PYRD_ACTPJA6VP48, PYRD_ACTSZ
A0KKK9, PYRD_AERHHA4SME2, PYRD_AERS4A9CK85, PYRD_AGRFC
B2UNA2, PYRD_AKKM8Q21WC4, PYRD_ALBFTQ5E5B6, PYRD_ALIF1
B5FE17, PYRD_ALIFMB6ELD1, PYRD_ALISLQ0A8M5, PYRD_ALKEH
B9JR03, PYRD_ALLAMB8JDF0, PYRD_ANAD2Q2IQI6, PYRD_ANADE
A7HD76, PYRD_ANADFB4UG99, PYRD_ANASKP32746, PYRD_ARATH
Q5P1A9, PYRD_AROAEA0JX31, PYRD_ARTS2A8HZX8, PYRD_AZOC5
A1K7M2, PYRD_AZOSBC1DDY1, PYRD_AZOVDA1URL3, PYRD_BARBK
Q6G4F7, PYRD_BARHEQ6G159, PYRD_BARQUA9IQ81, PYRD_BART1
Q1LT62, PYRD_BAUCHQ2KW44, PYRD_BORA1Q7WGE4, PYRD_BORBR
Q7W4W6, PYRD_BORPAA9I8M0, PYRD_BORPDQ7VTR9, PYRD_BORPE
Q5E9W3, PYRD_BOVINQ89VA7, PYRD_BRADUA5EA61, PYRD_BRASB
A4Z2G7, PYRD_BRASOB2S953, PYRD_BRUA1Q2YPG3, PYRD_BRUA2
A6WVY1, PYRD_BRUA4Q57F47, PYRD_BRUABA9M7Z9, PYRD_BRUC2
C0RH28, PYRD_BRUMBQ8YFB1, PYRD_BRUMEA5VNQ1, PYRD_BRUO2
B0CJU0, PYRD_BRUSIQ8G2K8, PYRD_BRUSUP57443, PYRD_BUCAI
Q8K9I5, PYRD_BUCAPA0K729, PYRD_BURCHB4E8N4, PYRD_BURCJ
Q0BFR0, PYRD_BURCMQ39GX5, PYRD_BURL3A9AJX4, PYRD_BURM1
A3MJ98, PYRD_BURM7A2S374, PYRD_BURM9Q62K45, PYRD_BURMA
A1V4A5, PYRD_BURMSQ1BWM4, PYRD_BURO1A3NUS1, PYRD_BURP0
Q3JSS8, PYRD_BURP1A3N925, PYRD_BURP6Q63TV1, PYRD_BURPS
Q2SVL9, PYRD_BURTAQ874I4, PYRD_CANALQ6SZS5, PYRD_CANGA
B3PIL8, PYRD_CELJUA3PN03, PYRD_CERS1Q3IZ94, PYRD_CERS4
B9KNA2, PYRD_CERSKQ11M76, PYRD_CHESBA9WDI1, PYRD_CHLAA
B9LHC1, PYRD_CHLSYA0M4D0, PYRD_CHRFKQ7NX17, PYRD_CHRVO
A8AID4, PYRD_CITK8A5CS38, PYRD_CLAM3B0RIK6, PYRD_CLASE
Q480K7, PYRD_COLP3Q6NH79, PYRD_CORDIQ8FTC6, PYRD_COREF
A4QEA4, PYRD_CORGBQ8NQC0, PYRD_CORGLQ9FB59, PYRD_CORST
B6J754, PYRD_COXB1B6J0A5, PYRD_COXB2A9KCF2, PYRD_COXBN
A9NCV1, PYRD_COXBRQ83CY0, PYRD_COXBUB1WUM4, PYRD_CROS5
A7MEW0, PYRD_CROS8Q1LP27, PYRD_CUPMCQ0KBT4, PYRD_CUPNH
Q472J6, PYRD_CUPPJB3R4T0, PYRD_CUPTRB8HW33, PYRD_CYAP4
P28294, PYRD_CYCAEQ47GW1, PYRD_DECARC1CX89, PYRD_DEIDV
Q1J132, PYRD_DEIGDQ9RX14, PYRD_DEIRAA9BWU2, PYRD_DELAS
A5EV79, PYRD_DICNVP32748, PYRD_DROMEA7ZK49, PYRD_ECO24
B7UN24, PYRD_ECO27B7MHP7, PYRD_ECO45B7LE45, PYRD_ECO55
P0A7E2, PYRD_ECO57B5YT76, PYRD_ECO5EB7NM29, PYRD_ECO7I
B7MS56, PYRD_ECO81B7M874, PYRD_ECO8AC4ZQ71, PYRD_ECOBW
B1X8P9, PYRD_ECODHA7ZYP7, PYRD_ECOHSA1A9L5, PYRD_ECOK1
Q0TJB6, PYRD_ECOL5Q8FJ91, PYRD_ECOL6B1IVY7, PYRD_ECOLC
P0A7E1, PYRD_ECOLIB7N3A7, PYRD_ECOLUB6I919, PYRD_ECOSE
B1LJR7, PYRD_ECOSMQ1RDR9, PYRD_ECOUTC5BD71, PYRD_EDWI9
A4W8V7, PYRD_ENT38Q75CE1, PYRD_EREGSB2VC84, PYRD_ERWT9
Q2N6N6, PYRD_ERYLHB7LNV5, PYRD_ESCF3A5FHT2, PYRD_FLAJ1
Q9F1U7, PYRD_FLALUA6H0L5, PYRD_FLAPJB8F848, PYRD_GLAP5
B7KIU7, PYRD_GLOC7Q7NC99, PYRD_GLOVIQ7VL56, PYRD_HAEDU
Q4QKB5, PYRD_HAEI8A5UC11, PYRD_HAEIEA5UEP8, PYRD_HAEIG
P45477, PYRD_HAEINQ2SCG9, PYRD_HAHCHA1WTJ3, PYRD_HALHL
Q5UYF1, PYRD_HALMAB0R808, PYRD_HALS3Q9HMK2, PYRD_HALSA
C4K4A3, PYRD_HAMD5Q17WU9, PYRD_HELAHB6JL11, PYRD_HELP2
B5Z6I2, PYRD_HELPGQ1CU70, PYRD_HELPHQ9ZM11, PYRD_HELPJ
B2USR9, PYRD_HELPSO25655, PYRD_HELPYA4G7T7, PYRD_HERAR
Q02127, PYRD_HUMANQ5QX65, PYRD_IDILOA6T106, PYRD_JANMA
A6WD43, PYRD_KINRDB5XY59, PYRD_KLEP3A6T739, PYRD_KLEP7
B2GHT4, PYRD_KOCRDQ6V3W9, PYRD_LACK1Q5X496, PYRD_LEGPA
A5ICX8, PYRD_LEGPCQ5ZUH7, PYRD_LEGPHQ5WVN0, PYRD_LEGPL
Q6AE78, PYRD_LEIXXB1Y3C1, PYRD_LEPCPQ65TR8, PYRD_MANSM
A6VW35, PYRD_MARMSA1TZG0, PYRD_MARN8B7KZJ5, PYRD_METC4
Q609J2, PYRD_METCAQ1H411, PYRD_METFKB3DX48, PYRD_METI4
B8ID11, PYRD_METNOA2SHQ5, PYRD_METPPO35435, PYRD_MOUSE
B1MPD4, PYRD_MYCA9P65909, PYRD_MYCBOA1KKI2, PYRD_MYCBP
C1AQ55, PYRD_MYCBTA4TB97, PYRD_MYCGIP46727, PYRD_MYCLE
B2HFZ1, PYRD_MYCMMQ73YS2, PYRD_MYCPAA0QZY9, PYRD_MYCS2
A3Q1C6, PYRD_MYCSJA1UHW0, PYRD_MYCSKQ1B765, PYRD_MYCSS
A5U4G5, PYRD_MYCTAP9WHL0, PYRD_MYCTOP9WHL1, PYRD_MYCTU
A0PQW5, PYRD_MYCUAA1TAT2, PYRD_MYCVPQ1D7Y6, PYRD_MYXXD
Q3IU78, PYRD_NATPDB9L9P6, PYRD_NAUPAQ5F605, PYRD_NEIG1
A9M3G1, PYRD_NEIM0Q9JX66, PYRD_NEIMAQ9K1D7, PYRD_NEIMB
A1KRQ4, PYRD_NEIMFQ0AIB4, PYRD_NITECQ82ST3, PYRD_NITEU
Q2Y5H8, PYRD_NITMUA6Q2V6, PYRD_NITSBQ5YVM8, PYRD_NOCFA
A1SJF2, PYRD_NOCSJB2IU79, PYRD_NOSP7Q8YPC6, PYRD_NOSS1
Q2GBY1, PYRD_NOVADQ7XKC8, PYRD_ORYSJA1TPZ2, PYRD_PARC0
A7HQ77, PYRD_PARL1Q7U3U2, PYRD_PARMWB2JKL9, PYRD_PARP8
Q13ZM3, PYRD_PARXLP57858, PYRD_PASMUQ6D456, PYRD_PECAS
C6DFC0, PYRD_PECCPQ7N617, PYRD_PHOLLQ6LRA2, PYRD_PHOPR
Q08210, PYRD_PLAF7A4SWU5, PYRD_POLAQA1VQJ1, PYRD_POLNA
B1XV77, PYRD_POLNSQ129L9, PYRD_POLSJQ5R6X6, PYRD_PONAB
B4EVC3, PYRD_PROMHQ7V473, PYRD_PROMMQ48JY0, PYRD_PSE14
Q15UB7, PYRD_PSEA6A6V325, PYRD_PSEA7B7UWL8, PYRD_PSEA8
Q02PL5, PYRD_PSEABQ9HZF8, PYRD_PSEAEB8H8Q4, PYRD_PSECP
Q1ICL4, PYRD_PSEE4Q4KFI7, PYRD_PSEF5C3K017, PYRD_PSEFS
A4XWQ0, PYRD_PSEMYQ3KFC7, PYRD_PSEPFB0KG90, PYRD_PSEPG
Q88L40, PYRD_PSEPKB1J5B5, PYRD_PSEPWQ883P1, PYRD_PSESM
Q3IGZ1, PYRD_PSET1Q4ZUM3, PYRD_PSEU2Q4FS74, PYRD_PSYA2
Q1QBS1, PYRD_PSYCKA1SX25, PYRD_PSYINA5WDZ3, PYRD_PSYWF
Q8XYY7, PYRD_RALN1Q63707, PYRD_RATB3PNN8, PYRD_RHIE6
Q2KCS8, PYRD_RHIECQ1MLT8, PYRD_RHIJ3Q98B89, PYRD_RHILO
B5ZPH6, PYRD_RHILWQ92S77, PYRD_RHIMEB9J901, PYRD_RHIR8
C0ZZY4, PYRD_RHOE4C1ASU1, PYRD_RHOOBQ2IR55, PYRD_RHOP2
Q07TQ6, PYRD_RHOP5Q6NBN1, PYRD_RHOPAQ13D13, PYRD_RHOPS
B3QEE3, PYRD_RHOPTQ2RX27, PYRD_RHORTB7JXU8, PYRD_RIPO1
A7NLW9, PYRD_ROSCSA5UX75, PYRD_ROSS1Q21JW9, PYRD_SACD2
B5F1U2, PYRD_SALA4A8LY18, PYRD_SALAIA9MHU3, PYRD_SALAR
Q57QU4, PYRD_SALCHB5FQY8, PYRD_SALDCB5QZE8, PYRD_SALEP
B5R8M3, PYRD_SALG2B4TDY5, PYRD_SALHSB4T1Y8, PYRD_SALNS
Q5PGE0, PYRD_SALPAA9N6Y4, PYRD_SALPBC0PVS5, PYRD_SALPC
B5BBM2, PYRD_SALPKB4TRW8, PYRD_SALSVQ8Z7S9, PYRD_SALTI
A4X619, PYRD_SALTOP25468, PYRD_SALTYP32747, PYRD_SCHPO
A8GCK4, PYRD_SERP5A1S5Z4, PYRD_SHEAMB8E984, PYRD_SHEB2
A3D5B9, PYRD_SHEB5A6WP30, PYRD_SHEB8A9L4D0, PYRD_SHEB9
Q12NG2, PYRD_SHEDOQ081J9, PYRD_SHEFNB0TIY0, PYRD_SHEHH
A3QDX8, PYRD_SHELPQ8EDZ8, PYRD_SHEONA8H3X8, PYRD_SHEPA
A4Y7I2, PYRD_SHEPCB8CPG0, PYRD_SHEPWA0KW50, PYRD_SHESA
A8FW61, PYRD_SHESHQ0HJL0, PYRD_SHESMQ0HVV6, PYRD_SHESR
A1RJ06, PYRD_SHESWB1KDM8, PYRD_SHEWMB2TUD4, PYRD_SHIB3
Q31YK8, PYRD_SHIBSQ32HW1, PYRD_SHIDSQ0T689, PYRD_SHIF8
Q83RX6, PYRD_SHIFLQ3Z3H6, PYRD_SHISSC3MFT0, PYRD_SINFN
A6U5U0, PYRD_SINMWQ2NU82, PYRD_SODGMQ1GVC1, PYRD_SPHAL
Q827Q6, PYRD_STRAWQ9KXR7, PYRD_STRCOB1W464, PYRD_STRGG
B4STK4, PYRD_STRM5B2FPI7, PYRD_STRMKA4VM41, PYRD_STUS1
Q30R79, PYRD_SULDNA6Q8G0, PYRD_SULNBQ31RJ7, PYRD_SYNE7
Q2JRL7, PYRD_SYNJAQ2JJF3, PYRD_SYNJBQ5N2Q8, PYRD_SYNP6
P74782, PYRD_SYNY3C5BKZ2, PYRD_TERTTQ47RF2, PYRD_THEFY
Q72KU3, PYRD_THET2Q5SK69, PYRD_THET8Q8DLB7, PYRD_THEVB
Q3SL21, PYRD_THIDAQ113R9, PYRD_TRIEIQ3MDU0, PYRD_TRIV2
A1WJ81, PYRD_VEREIB7VNK9, PYRD_VIBA3A7N0L2, PYRD_VIBC1
A5F839, PYRD_VIBC3Q9KRZ2, PYRD_VIBCHC3LMH4, PYRD_VIBCM
Q87PB7, PYRD_VIBPAQ8D9G5, PYRD_VIBVUQ7MKX3, PYRD_VIBVY
Q8D370, PYRD_WIGBRQ8PLJ2, PYRD_XANACQ4UTX5, PYRD_XANC8
B0RTS3, PYRD_XANCBQ8P9R0, PYRD_XANCPQ3BUJ7, PYRD_XANE5
Q2P3M0, PYRD_XANOMB2SLB9, PYRD_XANOPQ5H0N0, PYRD_XANOR
A7IBC2, PYRD_XANP2B2I9T5, PYRD_XYLF2Q9PAE7, PYRD_XYLFA
B0U5I1, PYRD_XYLFMQ87A77, PYRD_XYLFTA1JMP8, PYRD_YERE8
A7FJU2, PYRD_YERP3Q1CA44, PYRD_YERPAB2JYR8, PYRD_YERPB
Q8ZG91, PYRD_YERPEA9R7L2, PYRD_YERPGQ1CGJ0, PYRD_YERPN
A4TMZ3, PYRD_YERPPQ66CG4, PYRD_YERPSB1JQS0, PYRD_YERPY

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-